SMOC2, an intestinal stem cell marker, is an independent prognostic marker associated with better survival in colorectal cancers
SMOC2, an intestinal stem cell marker, is an independent prognostic marker associated with better survival in colorectal cancers
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DOI：
10.1038/s41598-020-71643-1
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发表时间：
2020-09-03
影响因子：
4.6
通讯作者：
Kang, Gyeong Hoon
中科院分区：
文献类型：
--
作者：
Jang, Bo Gun;Kim, Hye Sung;Kang, Gyeong Hoon
We aimed to investigate the expression profile of SPARC-related modular calcium-binding protein 2 (SMOC2) during colorectal cancer (CRC) progression and assess its prognostic impact in CRC patients. In our study, we showed that SMOC2 transcript level was higher in CRC samples than in normal mucosa (P=0.017); this level was not associated with candidate cancer stem cell markers (CD44, CD166, CD133, and CD24) or intestinal stem cell markers (LGR5, ASCL2, and EPHB2) except for OLFM4 (P=0.04). Immunohistochemical analysis showed that SMOC2-positive cells were confined to the crypt bases in the normal intestinal mucosa, hyperplastic polyps, and sessile serrated adenomas, whereas traditional serrated adenomas and conventional adenomas exhibited focal or diffuse distribution patterns. In total, 28% of 591 CRCs were positive for SMOC2, but SMOC2 positivity had negative correlations with lymphatic invasion (P=0.002), venous invasion (P=0.002), and tumor stage (P
