Pressor response buffering by beta-adrenergic and cholinergic vasodilation in tranquilized dogs.
Pressor response buffering by beta-adrenergic and cholinergic vasodilation in tranquilized dogs.
复制标题
镇静狗通过β-肾上腺素能和胆碱能血管舒张来缓冲升压反应。
DOI：
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发表时间：
1979
影响因子：
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通讯作者：
T. Lowery
中科院分区：
文献类型：
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作者：
J. Evans;C. Knapp;T. Lowery
Buffering of alpha-receptor-mediated pressor responses by beta-adrenergic or cholinergic vasodilation in tranquilized, chronically instrumented gos was investigated. Increases in aortic pressure were produced in the same animal by intravenous injections of phenylephrine in the control state and in three successive experimental states by 1) pacing the heart to remove the reflex capability to lower heart rate, 2) pacing the heart and beta-blockade to remove beta-adrenergic vascular buffering, and 3) beta-blockade plus atropine to also remove cholinergic vascular buffering. The pressor response in each experimental state was greater than that in the state preceding it. With the combined beta-adrenergic and cholinergic blockade, the pressor response to an alpha-receptor stimulation was three times greater than that of the control state. From an analysis of the components of the pressor response, cardiac output, and peripheral resistance, it is suggested that normal buffering of an alpha-mediated pressor response may include beta-adrenergic and cholinergic vascular dilation in addition to a decrease in heart rate.
