The interaction of P11 methylation and early-life stress impacts the antidepressant response in patients with major depressive disorder
The interaction of P11 methylation and early-life stress impacts the antidepressant response in patients with major depressive disorder
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P11 甲基化和早期生活压力的相互作用影响重度抑郁症患者的抗抑郁反应
DOI：
10.1016/j.jad.2022.06.042
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发表时间：
2022
影响因子：
6.6
通讯作者：
Yonggui Yuan
中科院分区：
文献类型：
--
作者：
Tianyu Wang;Lei Li;Yingying Yue;Xiaoyun Liu;Suzhen Chen;Tian Shen;Zhi Xu;Yonggui Yuan
本研究以291例汉族抑郁症患者和100名健康对照者为研究对象，探讨P11基因甲基化与生活应激对抑郁症患者前2周抗抑郁药疗效的影响。采用生活事件量表和儿童期创伤问卷进行压力评估。主要终点是治疗两周后的汉密尔顿抑郁评定量表-17减少率。采用Illumina HiSeq平台检测外周血标本中P11基因74个CpG位点的甲基化情况，MDD患者的P11-2-169、P11-2-192、P11-2-202、P11-2-204显著高于健康对照组（FDR校正P < 0.05）。对抗抑郁药的反应与以下相互作用相关：CTQ评分和P11-3-185位点甲基化（OR = 0.297，FDR校正P = 0.023），CTQ身体忽视评分和P11-2-117位点甲基化（OR = 0.005，FDR校正的P = 0.033），CTQ情感虐待评分和P11-3-185位点甲基化（OR = 0.001，FDR校正后P = 0.023）。抑郁症患者P11基因甲基化水平显著增高。P11 DNA甲基化和早期生活应激的相互作用可能会影响短期抗抑郁治疗反应。
The present research investigates the influence of P11 gene DNA methylation combined with life stress on the response to antidepressants in the first two weeks.A total of 291 Han Chinese patients with major depressive disorder and 100 healthy controls were included. The Life Events Scale and the Childhood Trauma Questionnaire were used to assess stress. The primary endpoint was the Hamilton Depression Rating Scale-17 reduction rate after two weeks of treatment. The Illumina HiSeq Platform was used to detect the methylation of 74 CpG sites of the P11 gene in peripheral blood samples.The mean methylation of all P11 CpG sites, as well as the methylation at 4 CpG sites (P11-2-169, P11-2-192, P11-2-202, P11-2-204), were significantly higher in patients with MDD than in healthy controls (FDR-corrected P < 0.05). The response to antidepressants was associated with the following interactions: the CTQ score and P11-3-185 site methylation (OR = 0.297, FDR-corrected P = 0.023), the CTQ physical neglect score and P11-2-117 site methylation (OR = 0.005, FDR-corrected P = 0.033), and the CTQ emotional abuse score and P11-3-185 site methylation (OR = 0.001, FDR-corrected P = 0.023).The methylation of the P11 gene was significantly higher in patients with major depressive disorder. The interaction of P11 DNA methylation and early-life stress may influence the short-term antidepressant treatment response.