Effect of Dai-kenchu-to on levels of 3 brain-gut peptides (motilin, gastrin and somatostatin) in human plasma
Effect of Dai-kenchu-to on levels of 3 brain-gut peptides (motilin, gastrin and somatostatin) in human plasma
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DOI：
10.1248/bpb.22.1131
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发表时间：
1999-10-01
影响因子：
2
通讯作者：
Takeyama, M
中科院分区：
文献类型：
--
作者：
Nagano, T;Itoh, H;Takeyama, M
本文观察了中药大建中汤（DKCT）对24名健康受试者血浆中胃动素、胃泌素和生长抑素三种脑肠肽水平的影响。与安慰剂组相比，DKCT单次口服7.5g，在60 ~ 90分钟时血浆胃动素水平显著升高（约12 pg/ml）。DKCT（25.9+/-1.4 pg/ml）和安慰剂（23.5+/-1.3 pg/ml）给药后均观察到胃泌素水平一过性升高。DKCT没有改变生长抑素的水平（约5.7 pg/ml）。总之，这些结果表明DKCT的作用与人血浆中胃动素免疫反应物质水平的变化密切相关。
We examined the effect of Dai-kenchu-to (DKCT), a traditional Chinese (Kampo) medicine, on the levels of 3 brain-gut peptides (motilin, gastrin and somatostatin) in plasma from 24 healthy subjects, A single oral administration of DKCT, at a dose of 7.5 g, caused significant increases in plasma motilin levels (about 12 pg/ml) at 60 to 90 min, compared with a placebo-treated group. Transient elevations of gastrin levels were noted after administration of both DKCT (25.9+/-1.4 pg/ml) and placebo (23.5+/-1.3 pg/ml). DKCT did not alter the levels (about 5.7 pg/ml) of somatostatin. In conclusion, these results indicate that the action of DKCT closely relates to changes in motilin-immunoreactive substance levels in human plasma.