A Mixed Component Supramolecular Hydrogel to Improve Mice Cardiac Function and Alleviate Ventricular Remodeling after Acute Myocardial Infarction
A Mixed Component Supramolecular Hydrogel to Improve Mice Cardiac Function and Alleviate Ventricular Remodeling after Acute Myocardial Infarction
复制标题
混合组分超分子水凝胶可改善小鼠心脏功能并减轻急性心肌梗塞后的心室重塑
DOI：
10.1002/adfm.201701798
复制
发表时间：
2017-09-13
影响因子：
19
通讯作者：
Ou, Caiwen
中科院分区：
文献类型：
--
作者：
Chen, Guoqin;Li, Jinliang;Ou, Caiwen
心肌梗死（MI）仍然是世界上导致死亡和残疾的主要原因，沿心肌梗死区周缘向心内注射生物材料（如水凝胶）被证明是治疗心肌梗死的有效方法。姜黄素具有抗炎症、抗氧化和抗细胞凋亡的特性，一氧化氮（NO）分子有利于血管生成。本研究制备了一种既能释放生物活性姜黄素又能释放NO的混合组分水凝胶用于治疗心肌梗死。研究表明，姜黄素和NO联合治疗可显著减少胶原沉积，改善心功能，改善不良心肌重构，抑制细胞凋亡。基质金属蛋白酶（MMPs）和转化生长因子- β1 （TGF - β1）的表达减弱，沉默信息调节因子1的表达上调，这是由于NO与姜黄素的协同作用和促进血管生成的能力。结果表明，通过水凝胶将姜黄素和一氧化氮以可控的方式共递送可能被认为是治疗心血管疾病的一种有希望的选择。
Myocardial infarction (MI) remains the major cause of death and disability in the world, and intramyocardial administration of biomaterials (e.g., hydrogels) along the perimeter of MI region is demonstrated as an effective way for the treatment of MI. The curcumin has anti‐inflammation, antioxidation, and antiapoptosis properties, and nitric oxide (NO) molecules are favorable for angiogenesis. This study prepares a mixed component hydrogel capable of releasing both bioactive curcumin and NO for the treatment of MI. The study shows that the combinational treatment of curcumin and NO can remarkably reduce collagen deposition, improve cardiac function, ameliorate adverse myocardium remodeling, suppress apoptosis, and hypertrophy as well as attenuate the expression of matrix metalloproteinases (MMPs) and transforming growth factor‐β1 (TGF‐β1) and upregulate the expression of silent information regulator 1 than curcumin alone, because of the synergistic action of both molecules and the angiogenesis promotion ability of NO. The results indicate that codelivery of curcumin and NO in a controllable manner by hydrogels might be considered as a promising option for treatment of cardiovascular disease.