Development of pulmonary arterial hypertension in women: interplay of sex hormones and pulmonary vascular disease.
Development of pulmonary arterial hypertension in women: interplay of sex hormones and pulmonary vascular disease.
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DOI：
10.2217/whe.09.88
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Hemnes AR
中科院分区：
文献类型：
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作者：
Pugh ME;Hemnes AR
肺动脉高压（PAH）是一种进行性肺血管疾病，最终导致右心衰竭和死亡。这种疾病在女性中占主导地位，尽管关于性别如何影响疾病发展知之甚少。最近的发展突出了雌激素代谢物在动物模型和人类疾病中的重要性，大大增加了我们对女性PAH的理解。本综述将重点关注PAH的一般知识、肺血管中性激素的转化和基础科学数据以及PAH女性患者特有的临床问题。未来的研究方向包括性激素对右心室反应的影响，提高对雌激素暴露对人类疾病影响的认识，以及脱氢表雄酮在基础科学和人类疾病中的研究。
Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature, ultimately resulting in right heart failure and death. This disease is strongly predominant in females, although little is known regarding how sex influences disease development. Recent developments highlighting the importance of estrogen metabolites in both animal models and human disease have substantially increased our understanding of PAH in women. This review will focus on general knowledge of PAH, translational and basic science data regarding sex hormones in the pulmonary vasculature and on clinical issues that are particular to women with PAH. Future directions for study include the influence of sex hormones on right ventricular responses, improving the understanding of the influence of estrogen exposure in human disease and the study of dehydroepiandrosterone in basic science and human disease.