Modulation of the host immune response as a result of Chlamydia psittaci infection.
Modulation of the host immune response as a result of Chlamydia psittaci infection.
复制标题
鹦鹉热衣原体感染导致的宿主免疫反应的调节。
DOI：
10.1128/iai.35.2.537-545.1982
复制
发表时间：
1982
影响因子：
3.1
通讯作者：
Wyrick,PB
中科院分区：
文献类型：
--
作者：
Lammert,JK;Wyrick,PB
给小鼠腹腔注射鹦鹉热衣原体原体的感染性、灭活或包膜制剂后，注射后 1 周和 2 周，脾细胞向有丝分裂剂刀豆球蛋白 A、植物血凝素和脂多糖的淋巴细胞转化显着减少。淋巴细胞反应在 4 周后恢复到对照值。同样，直到注射后 4 周才检测到衣原体抗原对细胞的转化。相比之下，注射非感染性细胞内网状体对细胞向刀豆球蛋白 A 的转化几乎没有影响。当对照脾细胞与感染性或灭活的基体体外孵育时，对所有三种有丝分裂原的反应也降低。添加有丝分裂原后越早添加生物体，转化的减少就越大。与初级体包膜和网状体一起孵育对脾细胞向伴刀豆球蛋白A的淋巴细胞转化没有影响。讨论了体外淋巴细胞转化测定中观察到的降低反应的能力与实际体内感染建立之间的关系。
After intraperitoneal injection of mice with infectious, inactivated, or envelope preparations of the elementary body of Chlamydia psittaci, lymphocyte transformation of spleen cells to the mitogens concanavalin A, phytohemagglutinin, and lipopolysaccharide was significantly reduced 1 and 2 weeks postinjection. Lymphocyte response returned to the control values by 4 weeks. Similarly, transformation of cells by chlamydial antigen was not detected until 4 weeks postinjection. Injection of the noninfectious intracellular reticulate body, in contrast, had little effect on transformation of cells to concanavalin A. When control spleen cells were incubated with infectious or inactivated elementary bodies in vitro, response to all three mitogens was also reduced. The sooner the organisms were added after the addition of mitogen, the greater the reduction in transformation. Incubation with elementary body envelopes and reticulate bodies had no effect on lymphocyte transformation of the spleen cells to concanavalin A. The relationship between the observed ability to reduce the response in the in vitro assay of lymphocyte transformation and the actual in vivo establishment of infection is discussed.