Anti-DNA and antilymphocyte antibodies during acute infection with human parvovirus B19.
Anti-DNA and antilymphocyte antibodies during acute infection with human parvovirus B19.
复制标题
人细小病毒 B19 急性感染期间的抗 DNA 和抗淋巴细胞抗体。
作者：
C. Solonínka;M. Anderson;C. Laskin
对细小病毒B19感染急性期和恢复期患者的血清以及未检测到抗细小病毒抗体的个体的血清进行了抗DNA和抗淋巴细胞抗体的检查。最近从细小病毒感染中恢复的个体中有68%的抗双链（ds）和抗单链（ss）DNA抗体水平升高。此外，超过88%的这些相同的血清中检测到细胞毒性IgM抗淋巴细胞抗体。还对实验性感染细小病毒B19的志愿者的系列标本进行了这些自身抗体的检测，并确定抗淋巴细胞IgM的存在取决于感染的阶段。抗淋巴细胞IgM偶见于风疹特异性IgM（11%）或水痘带状疱疹特异性IgM（25%）。然而，与B19感染相反，这些抗体没有细胞毒性。从我们的研究结果，我们提出，细小病毒感染的血液正常的个人可能伴随着一个短暂的，亚临床的自身免疫状态。
Sera from patients in the acute and recovery stages of parvovirus B19 infection, and from individuals with no detectable antiparvovirus antibody were examined for the presence of anti-DNA and antilymphocyte antibodies. Sixty-eight percent of individuals recently recovered from parvovirus infection had elevated levels of antidouble stranded (ds) and antisingle stranded (ss) DNA antibodies. In addition, a cytotoxic IgM antilymphocyte antibody was detected in more than 88% of these same sera. Serial specimens from volunteers experimentally infected with parvovirus B19 were also tested for these autoantibodies and it was determined that the presence of antilymphocyte IgM was dependent on the stage of infection. The antilymphocyte IgM was occasionally detectable in sera containing rubella specific IgM (11%) or varicella zoster specific IgM (25%). However, in contrast to B19 infection, these antibodies were not cytotoxic. From the results of our study, we propose that parvovirus infection of hematologically normal individuals may be accompanied by a transient, subclinical autoimmune state.