Effects of cerebellar dentate nucleus GABAergic cells on rat inferior olivary neurons
Effects of cerebellar dentate nucleus GABAergic cells on rat inferior olivary neurons
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DOI：
10.1097/00001756-200112040-00021
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发表时间：
2001-12-04
期刊：
影响因子：
1.7
通讯作者：
Perciavalle, V
中科院分区：
文献类型：
--
作者：
Garifoli, A;Scardilli, G;Perciavalle, V
本研究分析了在慢性破坏MDJ结构的大鼠中，激活小脑外侧核（LN）对下橄榄核（IO）神经元单位活动的影响，即在这种动物中，LN对IO的诱发作用应仅依赖于LN的GABA能细胞的激活。已经观察到，约三分之二的橄榄小脑神经元受到LN刺激的显著影响，并且>68%的这些细胞被抑制。三分之二的抑制反应与单突触联系兼容，而其余的抑制可能是由于多突触联系。大部分LN诱导的抑制被取消或大大减少应用GABA拮抗剂后。NeuroReport 12：3709-3713（C）2001 Lippincott威廉姆斯和威尔金斯。
The present study was undertaken to analyze the effects on unitary activity of inferior olive (IO) neurons elicited by activation of cerebellar lateral nucleus (LN), in rats submitted to the chronic destruction of MDJ structures, i.e. in animals in which the LN-evoked effects in IO should be depended only on activation of GABAergic cells of LN. It has been observed that about two-thirds of the olivocerebellar neurons are significantly affected by LN stimulation, and >68% of those cells were inhibited. Two-thirds of the inhibitory responses were compatible with a monosynaptic linkage, whereas the remaining inhibitions were probably due to polisynaptic linkages. The majority of LN-induced inhibitions was abolished or greatly reduced following application of GABA antagonists. NeuroReport 12:3709-3713 (C) 2001 Lippincott Williams & Wilkins.