Validation of the social communication questionnaire in a population cohort of children with autism spectrum disorders
Validation of the social communication questionnaire in a population cohort of children with autism spectrum disorders
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DOI：
10.1097/chi.0b013e31812f7d8d
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发表时间：
2007-10-01
影响因子：
13.3
通讯作者：
Pickles, Andrew
中科院分区：
文献类型：
--
作者：
Chandler, Susie;Charman, Tony;Pickles, Andrew
目的：研究自闭症谱系障碍（ASD）儿童和普通人群的社会沟通问卷（SCQ）的性质。方法：收集三个样本的SCQ数据：特殊需要和自闭症项目（SNAP） 9- 10岁有特殊教育需要的儿童（有和没有ASD）和两个相似但不同的年龄组的儿童（n = 411和n = 247）。诊断评估是在特殊教育需要组的分层子样本（n = 255）中完成的。样本加权程序使我们能够估计ASD总体人群中SCQ的特征。从儿童健康记录中提取一般人群样本中病例的诊断状态。结果：SCQ在ASD与非ASD之间（敏感性0.88，特异性0.72）和自闭症与非自闭症之间（敏感性0.90，特异性0.86）具有较强的区别。研究结果不受儿童智商或父母教育程度的影响。在一般人群样本中，有4%到5%的儿童得分高于自闭症分界点，其中1.5%的儿童得分高于自闭症分界点。虽然这些高分儿童中有许多被诊断为自闭症谱系障碍，但几乎所有（接近90%）的儿童都被诊断为神经发育障碍。结论：本研究证实了SCQ在学龄儿童高危样本中作为ASD一级筛查的效用。
Objective: To examine the properties of the Social Communication Questionnaire (SCQ) in a population cohort of children with autism spectrum disorders (ASDs) and in the general population, Method: SCQ data were collected from three samples: the Special Needs and Autism Project (SNAP) cohort of 9- to 10-year-old children with special educational needs with and without ASD and two similar but separate age groups of children from the general population (n = 411 and n = 247). Diagnostic assessments were completed on a stratified subsample (n = 255) of the special educational needs group. A sample-weighting procedure enabled us to estimate characteristics of the SCQ in the total ASD population. Diagnostic status of cases in the general population samples were extracted from child health records. Results: The SCQ showed strong discrimination between ASD and non-ASD cases (sensitivity 0.88, specificity 0.72) and between autism and nonautism cases (sensitivity 0.90, specificity 0.86). Findings were not affected by child IQ or parental education. In the general population samples between 4% and 5% of children scored above the ASD cutoff including 1.5% who scored above the autism cutoff. Although many of these high-scoring children had an ASD diagnosis, almost all (similar to 90%) of them had a diagnosed neurodevelopmental disorder. Conclusions: This study confirms the utility of the SCQ as a,first-level screen for ASD in at-risk samples of school-age children.