A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies.
A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies.
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DOI：
10.1016/j.tips.2017.03.011
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发表时间：
2017-07
影响因子：
13.8
通讯作者：
Frost B
中科院分区：
文献类型：
--
作者：
Orr ME;Sullivan AC;Frost B
目前还没有用于治疗 tau 病的疾病缓解疗法，tau 病是一组进行性神经退行性疾病，其病理学特征是大脑中存在 tau 蛋白聚集体。目前治疗 tau 蛋白病的挑战包括无法早期诊断和自信地区分患者中不同的 tau 蛋白病，以及对致病性 tau 蛋白诱导的神经元死亡和功能障碍所涉及的细胞机制的不完全了解。在这篇综述中，我们描述了当前的诊断和治疗策略、致病性 tau 形成的已知驱动因素、对我们目前对致病性 tau 如何诱导神经元死亡的机制理解的最新贡献，以及潜在的诊断和治疗方法。
There are currently no disease-modifying therapies for the treatment of tauopathies, a group of progressive neurodegenerative disorders that are pathologically defined by the presence of tau protein aggregates in the brain. Current challenges for the treatment of tauopathy include the inability to diagnose early and to confidently discriminate between distinct tauopathies in patients, alongside an incomplete understanding of the cellular mechanisms involved in pathogenic tau-induced neuronal death and dysfunction. In this review, we describe current diagnostic and therapeutic strategies, known drivers of pathogenic tau formation, recent contributions to our current mechanistic understanding of how pathogenic tau induces neuronal death, and potential diagnostic and therapeutic approaches.