N6-methyladenosine regulatory machinery in plants: composition, function and evolution
N6-methyladenosine regulatory machinery in plants: composition, function and evolution
复制标题
植物中的 N6-甲基腺苷调节机制：组成、功能和进化
DOI：
10.1111/pbi.13149
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发表时间：
2019
影响因子：
13.8
通讯作者：
Song Weining
中科院分区：
文献类型：
--
作者：
Yue Hong;Nie Xiaojun;Yan Zhaogui;Song Weining
N6甲基腺苷（m6A） RNA甲基化是一种保守的转录后机制，可丰富和调节真核生物的遗传信息，是RNA最关键的内部修饰之一。这种修饰在植物中的范围和作用一直是研究的热点，特别是在模式植物系统中。植物m6A写入器、擦除器和读取器的表征及其功能的阐明是目前植物生物学研究中最引人关注的热点之一。在可预见的未来，植物中m6A的功能分析将蓬勃发展，这将有助于通过表观转录组操作进行作物遗传改良。本文就植物m6A调控机制的结构和组成以及m6A在植物生长发育和逆境响应中的生物学功能等方面的研究进展进行了系统的分析和综述。最后，我们的分析表明，m6A修饰组分之间的进化关系在整个植物界高度保守。
N6‐methyladenosine (m6A) RNA methylation, one of the most pivotal internal modifications of RNA, is a conserved post‐transcriptional mechanism to enrich and regulate genetic information in eukaryotes. The scope and function of this modification in plants has been an intense focus of study, especially in model plant systems. The characterization of plant m6A writers, erasers and readers, as well as the elucidation of their functions, is currently one of the most fascinating hotspots in plant biology research. The functional analysis of m6A in plants will be booming in the foreseeable future, which could contribute to crop genetic improvement through epitranscriptome manipulation. In this review, we systematically analysed and summarized recent advances in the understanding of the structure and composition of plant m6A regulatory machinery, and the biological functions of m6A in plant growth, development and stress response. Finally, our analysis showed that the evolutionary relationships between m6A modification components were highly conserved across the plant kingdom.