Gene transfer of human TCR in primary murine T cells is improved by pseudo‐typing with amphotropic and ecotropic envelopes
Gene transfer of human TCR in primary murine T cells is improved by pseudo‐typing with amphotropic and ecotropic envelopes
复制标题
通过兼嗜性和共嗜性包膜的假分型改善了原代鼠 T 细胞中人类 TCR 的基因转移
作者：
N. Pouw;Elike J Westerlaken;R. Willemsen;R. Debets
T细胞受体（TCR）基因治疗是一种有吸引力的抗癌治疗方法，但需要在临床相关模型中进一步优化其疗效和安全性，例如使用肿瘤抗原和人源TCR的模型。然而，目前，对于将逆转录病毒人TCR基因转移到原代鼠T细胞中的最佳方案没有达成共识，最值得注意的是关于病毒假型。
T cell receptor (TCR) gene therapy represents an attractive anti‐cancer treatment but requires further optimization of its efficacy and safety in clinically relevant models, such as those using a tumor antigen and TCR of human origin. Currently, however, there is no consensus as to what protocol is most optimal for retroviral human TCR gene transfer into primary murine T cells, most notably with respect to virus pseudo‐type.
影响因子：
45.3
作者：
Dudley, ME;Wunderlich, JR;Rosenberg, SA
通讯作者：
Rosenberg, SA