Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival.
Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival.
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LANCL1的发育和活性依赖性表达赋予神经元存活所需的抗氧化活性。
DOI：
10.1016/j.devcel.2014.06.011
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发表时间：
2014-08-25
影响因子：
11.8
通讯作者：
Xiao, Bo
中科院分区：
文献类型：
--
作者：
Huang, Chao;Chen, Mina;Pang, Dejiang;Bi, Dandan;Zou, Yi;Xia, Xiaoqiang;Yang, Weiwei;Luo, Liping;Deng, Rongkang;Tan, Honglin;Zhou, Liang;Yu, Shouyang;Guo, Liheng;Du, XiaoXia;Cui, Yiyuan;Hu, Jiahua;Mao, Qing;Worley, Paul F.;Xiao, Bo
Production of reactive oxygen species (ROS) increases with neuronal activity that accompanies synaptic development and function. Transcription-related factors and metabolic enzymes that are expressed in all tissues have been described to counteract neuronal ROS to prevent oxidative damage. Here, we describe the antioxidant gene LanCL1 that is prominently enriched in brain neurons. Its expression is developmentally regulated and induced by neuronal activity, neurotrophic factors implicated in neuronal plasticity and survival, and oxidative stress. Genetic deletion of LanCL1 causes enhanced accumulation of ROS in brain, and development-related lipid, protein, and DNA damage, mitochondrial dysfunction and apoptotic neurodegeneration. LanCL1 transgene protects neurons from ROS. LanCL1 protein purified from eukaryotic cells catalyzes the formation of thioether products similar to glutathione S-transferase. These studies reveal a neuron-specific glutathione defense mechanism that is essential for neuronal function and survival.
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影响因子：
25
作者：
通讯作者：
--
影响因子：
4.8
作者：
Ho, YS;Xiong, Y;Ho, DS
通讯作者：
Ho, DS
影响因子：
64.8
作者：
Brakeman, PR;Lanahan, AA;Worley, PF
通讯作者：
Worley, PF
影响因子：
64.5
作者：
Mugoni V;Postel R;Catanzaro V;De Luca E;Turco E;Digilio G;Silengo L;Murphy MP;Medana C;Stainier DY;Bakkers J;Santoro MM
通讯作者：
Santoro MM
DOI：
10.1006/bbrc.2000.3260
发表时间：
2000-08-18
影响因子：
3.1
作者：
Bauer, H;Mayer, H;Prohaska, R
通讯作者：
Prohaska, R