Performance-related sustained and anticipatory activity in human medial temporal lobe during delayed match-to-sample.
Performance-related sustained and anticipatory activity in human medial temporal lobe during delayed match-to-sample.
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DOI：
10.1523/jneurosci.2245-09.2009
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发表时间：
2009-09-23
期刊：
影响因子：
--
通讯作者：
Wagner AD
中科院分区：
文献类型：
--
作者：
Olsen RK;Nichols EA;Chen J;Hunt JF;Glover GH;Gabrieli JD;Wagner AD
内侧颞叶（MTL）-海马及其周围的嗅周、海马旁和内嗅皮质区-长期以来被认为对事件的长期记忆至关重要。最近的功能性神经影像学和神经心理学数据在人类执行短延迟任务表明，MTL也有助于性能，即使保持时间间隔很短，和啮齿动物的单单位数据显示持续的，性能相关的延迟活动在MTL延迟非匹配到样本的任务。目前的研究使用功能磁共振成像（fMRI），以检查在人类MTL亚区的激活和性能之间的关系，在延迟匹配到样本的任务与重复（非试验独特）的刺激。在关键的试验中，呈现两张面孔之后是30秒的延迟期，之后参与者进行两种选择的强迫选择识别。功能磁共振成像显示显着的延迟期活动在前海马，内嗅皮层，和嗅周皮层超过30秒的保留时间间隔，与活动的幅度显着较高的随后正确的相比，随后不正确的试验。相比之下，后海马，海马旁皮质，梭状回的活动线性增加整个30秒的延迟，这表明一个预期的反应，和活动在海马旁皮质和海马是更大的探测期间正确的不正确的试验相比。这些结果表明，至少有两种模式的MTL延迟期激活-持续和预期-存在于性能的短延迟识别记忆任务，提供了新的证据，多个进程管理任务的性能。理解的海马和周围的MTL皮质区在识别记忆的作用后，短暂的延迟的影响进行了讨论。
The medial temporal lobe (MTL)—hippocampus and surrounding perirhinal, parahippocampal, and entorhinal cortical areas—has long been known to be critical for long-term memory for events. Recent functional neuroimaging and neuropsychological data in humans performing short-delay tasks suggest that the MTL also contributes to performance even when retention intervals are brief, and single-unit data in rodents reveal sustained, performance-related delay activity in the MTL during delayed-non-match-to-sample tasks. The current study used functional MRI (fMRI) to examine the relationship between activation in human MTL subregions and performance during a delayed-match-to-sample task with repeated (non-trial unique) stimuli. On critical trials, the presentation of two faces was followed by a 30-s delay period, after which participants performed two-alternative forced choice recognition. Functional MRI revealed significant delay-period activity in anterior hippocampus, entorhinal cortex, and perirhinal cortex over the 30-s retention interval, with the magnitude of activity being significantly higher on subsequently correct compared to subsequently incorrect trials. By contrast, posterior hippocampus, parahippocampal cortex, and fusiform gyrus activity linearly increased across the 30-s delay, suggesting an anticipatory response, and activity in parahippocampal cortex and hippocampus was greater during the probe period on correct compared to incorrect trials. These results indicate that at least two patterns of MTL delay-period activation—sustained and anticipatory—are present during performance of short-delay recognition memory tasks, providing novel evidence that multiple processes govern task performance. Implications for understanding the role of the hippocampus and surrounding MTL cortical areas in recognition memory after short delays are discussed.