Ectopic adrenocorticotropic hormone syndrome.
Ectopic adrenocorticotropic hormone syndrome.
复制标题
异位促肾上腺皮质激素综合征。
DOI：
10.1210/edrv-15-6-752
复制
发表时间：
1994
影响因子：
20.3
通讯作者：
M. Kirschner
中科院分区：
文献类型：
--
作者：
B. Wajchenberg;B. Mendonca;B. Liberman;M. A. Pereira;P. C. Carneiro;A. Wakamatsu;M. Kirschner
肿瘤产生激素和其他蛋白质标记物一直是肿瘤生物学的一个有趣领域。在过去的几十年里，人们已经清楚地发现，各种内分泌肿瘤分泌通常与肿瘤发生的腺体无关的激素，并且非内分泌肿瘤可以合成和/或分泌多肽激素和其他肿瘤相关蛋白。当标记物与肿瘤来源的组织不明显相关时，这种肿瘤标记物的产生被称为“异位的”或“不适当的”。最初，由癌症引起的异位激素分泌被认为是罕见或不寻常的，但随着现代激素检测技术的使用，这些综合征被认为是常见的。事实上，奥德尔等人（1）已经假设所有肿瘤都产生POMC和其他蛋白质标志物。Meador等（2）提出了这样的概念，即某些“非内分泌”组织的肿瘤可通过分泌肾上腺素而引起库欣综合征。
THE production of hormones and other protein markers by tumors has been an intriguing area of tumor biology. It has become apparent during the last decades that a wide range of endocrine tumors secrete hormones not normally associated with the gland in which the neoplasm arises and that nonendocrine tumors can synthesize and/or secrete polypeptide hormones and other tumor-associated proteins. The production of such tumor markers has come to be referred to as “ectopic” or “inappropriate” when the marker is not obviously associated with the tissue from which the tumor derives. Initially the presence of ectopic hormone secretion caused by cancer was considered as rare or unusual, but with the use of modern techniques of hormone detection these syndromes are felt to be common. Indeed, Odell et al. (1) have postulated that all tumors make POMC and other protein markers. Meador et al. (2) developed the concept that certain tumors of “nonendocrine” tissues can give rise to Cushing's syndrome by secreting an adre...