Sarcopenia: Prevalence, Mechanisms, and Functional Consequences
Sarcopenia: Prevalence, Mechanisms, and Functional Consequences
复制标题
DOI：
10.1159/000319997
复制
发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Doherty, Timothy J.
中科院分区：
文献类型：
--
作者：
Berger, Michael J.;Doherty, Timothy J.
衰老与神经肌肉功能和表现的显著下降有关。肌肉减少症，通常定义为与年龄相关的肌肉质量、力量和功能下降的损失，是神经肌肉系统中与年龄相关的变化的最典型特征。上肢和下肢肌肉的力量下降通常是20-40%的第七个十年和更大的老年人。这伴随着肢体肌肉横截面积的类似损失。全身或四肢肌肉质量测定已成为定义肌肉减少症的首选方法。大型人群研究报告称，肌肉减少症影响超过20%的60至70岁的人，在75岁以上的人中接近50%。虽然肌肉质量的损失解释了虚弱的一个重要组成部分，但其他因素正在成为重要的贡献者。特别是在运动神经元和运动单位的水平上的变化进行了讨论。肌肉力量已经成为老年人功能的一个重要指标，我们讨论膝关节骨关节炎作为加速肢体肌肉减少症的模型。版权所有（C）2010 S. Karger AG，巴塞尔
Aging is associated with significant decline in neuromuscular function and performance. Sarcopenia, often defined as age-related loss of muscle mass, strength, and functional decline, is the most characteristic feature of age-related changes in the neuromuscular system. Strength decline in upper and lower limb muscles is typically 20-40% by the 7th decade and greater in older adults. This is accompanied by similar losses of limb muscle cross-sectional area. Whole body or appendicular muscle mass determination has become the method of choice for defining sarcopenia. Large population studies have reported that sarcopenia affects over 20% of 60- to 70-year-olds, and approaches 50% in those over 75 years. While loss of muscle mass explains a significant component of weakness, other factors are emerging as important contributors. In particular changes at the level of the motor neuron and motor unit are discussed. Muscle power has emerged as an important indicator of function in older adults, and we discuss knee osteoarthritis as a model of accelerated limb sarcopenia. Copyright (C) 2010 S. Karger AG, Basel