RESPONSE OF JUVENILE CENTRARCHIDS TO SUBLETHAL CONCENTRATIONS OF WATERBORNE SELENIUM .1. UPTAKE, TISSUE DISTRIBUTION, AND RETENTION
RESPONSE OF JUVENILE CENTRARCHIDS TO SUBLETHAL CONCENTRATIONS OF WATERBORNE SELENIUM .1. UPTAKE, TISSUE DISTRIBUTION, AND RETENTION
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DOI：
10.1016/0166-445x(82)90027-3
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发表时间：
1982-01-01
影响因子：
4.5
通讯作者：
LEMLY, AD
中科院分区：
文献类型：
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作者：
LEMLY, AD
经10微克/L染毒120天后，幼鱼(Lepomis Macchirus)和大口黑鱼(Micropterus Salmoides)各组织中的Se含量均显著升高。硒在特定组织中的相对积累量为：脾>；心>；肝>；肾>；红细胞>；鳃>；血浆>；白肌>；性腺>；肠>；胃>；脑。水温和硬度不影响90天后观察到的平衡浓度或组织分布，尽管早期的数值受到影响。在30天的消除试验后，脾、肝、肾和白色肌肉中的硒浓度保持不变，但显示出半衰期。在鳃和红细胞中存活15天。种间差异最大的是白色肌肉中的硒含量，其中蓝鳃集中，大约是大口黑鱼的两倍。主要的摄取途径是由Se-离子上的活性氧基介导的红细胞转运，随后在优先部位进行交换。脾和心脏的高比例可能受到硒蛋白形成差异的影响。尽管在这些受控的实验条件下没有导致死亡，但可能的病理增强，加上饮食摄入增加的身体负担，表明在水中硒浓度接近10微克/L的自然系统中存在潜在的毒性。
Juvenile bluegill (Lepomis macrochirus) and largemouth bass (Micropterus salmoides) contained significantly elevated levels of Se in all tissues after exposure to 10 .mu.g/l for 120 days. The relative accumulation of Se in specific tissues was as follows: spleen > heart > liver > kidney > erythrocytes > gill > plasma > white muscle > gonad > intestine > stomach > brain. Water temperature and hardness did not affect the equilibrium concentrations or tissue distribution observed after 90 days, although earlier values were influenced. Se concentrations remained unchanged after 30-day elimination trials in spleen, liver, kidney and white muscle but exhibited a half-life retention time .ltoreq. 15 days in gill and erythrocytes. The largest difference between species was in the Se content of white muscle, with bluegill concentrating, approximately twice that of largemouth bass. The major uptake pathway was erythrocyte transport mediated by active oxo-groups on the Se anion, with subsequent exchange at preferential sites. High apportionment into the spleen and heart may have been influenced by differential formation of selenoproteins. Even though no mortality resulted under these controlled experimental conditions, possible pathologic enhancement, combined with the added body burden from dietary intake, suggested the potential for toxicity in natural systems where waterborne Se concentrations approached 10 .mu.g/l.