Corticotropin-releasing hormone and cortisol: longitudinal associations with depression and antisocial behavior in pregnant adolescents.
Corticotropin-releasing hormone and cortisol: longitudinal associations with depression and antisocial behavior in pregnant adolescents.
复制标题
促肾上腺皮质激素释放激素和皮质醇：与怀孕青少年抑郁和反社会行为的纵向关联。
DOI：
10.1097/00004583-199904000-00020
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Chrousos,GP
中科院分区：
文献类型：
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作者：
Susman,EJ;Schmeelk,KH;Worrall,BK;Granger,DA;Ponirakis,A;Chrousos,GP
目的探讨怀孕青少年中促肾上腺皮质激素释放激素（CRH）和皮质醇浓度与抑郁和反社会行为（行为障碍症状）之间的同时和纵向关联。方法对 59 名青少年在怀孕早期（妊娠 9-21 周）、妊娠晚期（妊娠 32-34 周）和产后期（产后 4-5 周）进行评估。抑郁症和行为障碍的症状是从儿童诊断访谈表中获得的。结果较低的 CRH 浓度与妊娠早期 (p < .05) 和妊娠晚期 (p < .05) 较多的抑郁症状有关。较低浓度的 CRH 还与妊娠早期 (p < .06) 和产后期 (p < .05) 较多的品行障碍症状有关。 结论 研究结果支持了长期存在的假设，即下丘脑 - 垂体 - 肾上腺轴的压力相关产物与怀孕期间的情绪和行为有关。 J. Am.阿卡德。儿童青少年。精神病学，1999，38(4)：460–467。
OBJECTIVETo examine the concurrent and longitudinal associations between corticotropin-releasing hormone (CRH) and cortisol concentrations and depression and antisocial behavior (conduct disorder symptoms) in pregnant adolescents.METHODFifty-nine adolescents were evaluated in early pregnancy (9–21 weeks' gestation), late pregnancy (32–34 weeks' gestation), and the postpartum period (4–5 weeks postpartum). Symptoms of depression and conduct disorder were obtained from the Diagnostic Interview Schedule for Children.RESULTSLower concentrations of CRH were related to a greater number of depression symptoms in early pregnancy (p < .05) and in late pregnancy (p <.05). Lower concentrations of CRH also were related to a greater number of conduct disorder symptoms in early pregnancy (p < .06) and in the postpartum period (p < .05).CONCLUSIONThe findings support the long-standing hypothesis that stress-related products of the hypothalamic-pituitary-adrenal axis are associated with emotions and behavior during pregnancy. J. Am. Acad. Child Adolesc. Psychiatry, 1999, 38(4):460–467.