Brief Report: A Longitudinal Study of Excessive Smiling and Laughing in Children with Angelman Syndrome
Brief Report: A Longitudinal Study of Excessive Smiling and Laughing in Children with Angelman Syndrome
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DOI：
10.1007/s10803-015-2404-y
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发表时间：
2015-08-01
影响因子：
3.9
通讯作者：
Oliver, Chris
中科院分区：
文献类型：
--
作者：
Adams, Dawn;Horsler, Kate;Oliver, Chris
大声笑和微笑是天使综合征行为表型的一个关键特征，横断面研究报告了随环境和年龄的变化。这项研究比较了 12 名参与者在三个实验条件下（完全社交互动（有眼神接触）、没有眼神接触的社交互动、仅近距离接触）的两个数据点的大笑和微笑水平。在任何情况下，随着时间的推移，大笑和微笑的频率都没有差异。然而，以年龄作为协变量，仅在完全社交互动（眼神交流）条件下，大笑和微笑的频率随着时间的推移而减少。由于这是第一个探索天使综合征中这些行为的纵向研究，因此结果表明行为表型内存在基因-环境-时间相互作用。
Elevated laughing and smiling is a key characteristic of the Angelman syndrome behavioral phenotype, with cross-sectional studies reporting changes with environment and age. This study compares levels of laughing and smiling in 12 participants across three experimental conditions [full social interaction (with eye contact), social interaction with no eye contact, proximity only] at two data points. No differences were noted in frequency of laughing and smiling over time in any condition. However, with age as a covariate, the frequency of laughing and smiling decreased over time in the full social interaction (with eye contact) condition only. As this is the first longitudinal study to explore these behaviors in Angelman syndrome, the results suggest a gene-environment-time interaction within the behavioral phenotype.