Lower treatment intensity and poorer survival in metastatic colorectal cancer patients who live alone
Lower treatment intensity and poorer survival in metastatic colorectal cancer patients who live alone
复制标题
DOI：
10.1038/bjc.2012.186
复制
发表时间：
2012-06-26
影响因子：
8.8
通讯作者：
Sorbye, H.
中科院分区：
文献类型：
--
作者：
Cavalli-Bjorkman, N.;Qvortrup, C.;Sorbye, H.
BACKGROUND: Socioeconomic status (SES) and social support influences cancer survival. If SES and social support affects cancer treatment has not been thoroughly explored.METHODS: A cohort consisting of all patients who were initially diagnosed with or who developed metastatic colorectal cancer (mCRC, n = 781) in three Scandinavian university hospitals from October 2003 to August 2006 was set up. Clinical and socioeconomic data were registered prospectively.RESULTS: Patients living alone more often had synchronous metastases at presentation and were less often treated with combination chemotherapy than those cohabitating (HR 0.19, 95% CI 0.04-0.85, P = 0.03). Surgical removal of metastases was less common in patients living alone (HR 0.29, 95% CI 0.10-0.86, P = 0.02) but more common among university-educated patients (HR 2.22, 95% CI 1.10-4.49, P = 0.02). Smoking, being married and having children did not influence treatment or survival. Median survival was 7.7 months in patients living alone and 11.7 months in patients living with someone (P < 0.001). Living alone remained a prognostic factor for survival after correction for age and comorbidity.CONCLUSION: Patients living alone received less combination chemotherapy and less secondary surgery. Living alone is a strong independent risk factor for poor survival in mCRC. British Journal of Cancer (2012) 107, 189-194. doi:10.1038/bjc.2012.186 www.bjcancer.com Published online 10 May 2012 (C) 2012 Cancer Research UK
