Acoustic responses of monodisperse lipid-encapsulated microbubble contrast agents produced by flow focusing.
Acoustic responses of monodisperse lipid-encapsulated microbubble contrast agents produced by flow focusing.
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DOI：
10.1179/175889610x12779105661532
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发表时间：
2010-12-01
期刊：
影响因子：
--
通讯作者：
Dayton, Paul A
中科院分区：
文献类型：
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作者：
Kaya, Mehmet;Feingold, Steven;Dayton, Paul A
脂质包封的微泡在超声成像中用作造影剂。目前市售的造影剂具有多分散的尺寸分布。已经假设可以用均匀的微泡半径实现改善的成像灵敏度。我们最近开发了微流体技术，以生产具有几乎单分散分布的造影剂。在这篇手稿中，我们分析了从单分散人口的单个微泡的回波响应，以建立散射回波，微泡半径和激发频率之间的关系。从一个修改后的瑞利-Plesset型模型的气泡响应的模拟证实了实验数据。结果表明，微气泡半径和声激励频率的最佳组合可以大大提高微气泡的回波响应。这些结果可能对造影剂的配制产生重大影响，以提高超声灵敏度。
Lipid-encapsulated microbubbles are used as contrast agents in ultrasound imaging. Currently available commercially made contrast agents have a polydisperse size distribution. It has been hypothesised that improved imaging sensitivity could be achieved with a uniform microbubble radius. We have recently developed microfluidics technology to produce contrast agents with a nearly monodisperse distribution. In this manuscript, we analyze echo responses from individual microbubbles from monodisperse populations in order to establish the relationship between scattered echo, microbubble radius, and excitation frequency. Simulations of bubble response from a modified Rayleigh-Plesset type model corroborate experimental data. Results indicate that microbubble echo response can be greatly increased by optimal combinations of microbubble radius and acoustic excitation frequency. These results may have a significant impact in the formulation of contrast agents to improve ultrasonic sensitivity.