Determining the longitudinal relaxation time (T1) of blood at 3.0 tesla
Determining the longitudinal relaxation time (T1) of blood at 3.0 tesla
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DOI：
10.1002/mrm.20178
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发表时间：
2004-09-01
影响因子：
3.3
通讯作者：
van Zijl, PCM
中科院分区：
文献类型：
--
作者：
Lu, HZ;Clingman, C;van Zijl, PCM
确定血液的纵向弛豫时间对于黑血成像以及通过动脉自旋标记 (ASL) 量化血流非常重要。在本研究中，使用循环系统在新的临床场强 3.0T 的生理条件下测量血液 T-1。结果发现，s(-1) 中的 1/T-1 在 0.38-0.46 的正常范围内与血细胞比容 (Hct) 呈线性相关 (P < 0.05)。关系为 1/T-1 = (0.52 +/- 0.15)。动脉血（氧合 = 92% +/- 7%）和静脉血（69% +/- 8%）分别为 Hct + (0.38 +/- 0.06) 和 1/T-1 = (0.83 +/- 0.07) Hct + (0.28 +/- 0.03)，这导致估计的 T-1 值为 1664 +/- 14 ms（动脉）和1584 +/- 5 ms（静脉），典型人类 Hct 为 0.42。当 Hct 值为 0.42 和 0.38 时，血液 T-1 的温度依赖性分别为 22.3 +/- 0.6 ms/℃ 和 19.8 +/- 0.8 ms/℃。当使用头部线圈发射/接收设置时，辐射阻尼导致测量的 T-1 值略有减少（19 毫秒）。 (C) 2004 Wiley-Liss, Inc.
It is important to determine the longitudinal relaxation time of blood for black blood imaging, as well as for quantifying blood flow by arterial spin labeling (ASL). In this study a circulation system was used to measure blood T-1 under physiological conditions at the new clinical field strength of 3.0T. It was found that 1/T-1 in s(-1) was linearly dependent (P < 0.05) on hematocrit (Hct) within a normal range of 0.38-0.46. The relationships were 1/T-1 = (0.52 +/- 0.15). Hct + (0.38 +/- 0.06) and 1/T-1 = (0.83 +/- 0.07) Hct + (0.28 +/- 0.03) for arterial (oxygenation = 92% +/- 7%) and venous blood (69% +/- 8%), respectively, which led to estimated T-1 values of 1664 +/- 14 ms (arterial) and 1584 +/- 5 ms (venous) at a typical human Hct of 0.42. The temperature dependencies of blood T-1 were 22.3 +/- 0.6 ms/ degreesC and 19.8 +/- 0.8 ms/degreesC for Hct values of 0.42 and 0.38, respectively. When a head coil transmit/receive setup was used, radiation damping caused a slight reduction (19 ms) of the measured T-1 values. (C) 2004 Wiley-Liss, Inc.