Clinical use of nicotine chewing-gum.
Clinical use of nicotine chewing-gum.
复制标题
尼古丁口香糖的临床应用。
DOI：
10.1136/bmj.280.6231.1599
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发表时间：
1980
影响因子：
--
通讯作者：
M. Jarvis
中科院分区：
文献类型：
--
作者：
M. Russell;M. Raw;M. Jarvis
尼古丁口香糖最近在英国已可供医生使用，以帮助戒烟。它产生的血液尼古丁浓度类似于吸烟，因此缓解尼古丁戒断症状。然而，部分由于尼古丁通过口腔粘膜吸收的速度较慢，它不能再现吸烟的快感。事实上，在早期阶段，它通常有点令人厌恶。在需要练习和仔细指导的技能中的最佳使用。由于它是一种辅助手段，而不是容易治愈，因此它的使用仅限于想要戒烟的吸烟者。早期的试验显示，与安慰剂相比，口香糖有一定的优势，但口香糖的改进和更多的使用经验表明，长期成功率可达40%或更高。它需要很少的时间来管理，因此是一个可行的方法，为忙碌医生。
Nicotine chewing-gum has recently become available to doctors in Britain for use as an aid to giving up smoking. It produces blood nicotine concentrations similar to tobacco smoking and so relieves symptoms of nicotine withdrawal. Owing partly to the slower rate of absorption of nicotine through the buccal mucosa, however, it does not reproduce the pleasure of cigarette smoking. Indeed, in the early stages it is usually slightly aversive. Optimal use in a skill requiring practice and careful instruction. Since it is an aid rather than easy cure, its use is limited to smokers who want to stop. Earlier trials showed modest advantages over placebo, but improvements in the gum and more experience in its use suggest that long-term success rates of 40% or more can be obtained. It required little time to administer and is therefore a feasible method for busy doctors.