EFFECT OF CYCLOSPORINE-A AND OLIGOMYCIN ON NONSPECIFIC PERMEABILITY OF THE INNER MITOCHONDRIAL-MEMBRANE
EFFECT OF CYCLOSPORINE-A AND OLIGOMYCIN ON NONSPECIFIC PERMEABILITY OF THE INNER MITOCHONDRIAL-MEMBRANE
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DOI：
10.1016/0014-5793(90)81245-j
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发表时间：
1990-09-17
期刊：
影响因子：
3.5
通讯作者：
KUDRJASHOV, YB
中科院分区：
文献类型：
--
作者：
NOVGORODOV, SA;GUDZ, TI;KUDRJASHOV, YB
本文研究了低霉素和环孢素A对Ca2+诱导线粒体内膜非特异性通透性的影响。寡霉素和环孢素A均能阻止非特异性通透性的激活，但环孢素A是唯一能恢复线粒体内膜初始通透性的药物。环孢素A的作用被证明不是通过Ca2+在不同线粒体亚群之间的再分配介导的
The effect of oligomycin and cyclosporine A on the induction of non‐specific permeability of the inner mitochondrial membrane by Ca2+was under study. Both oligomycin and cyclosporine A were able to prevent the activation of non‐specific permeability, but cyclosporine A was the only agent which could restore initial permeability of the inner mitochondrial membrane. The effect of cyclosporine A was shown not to be mediated through redistribution of Ca2+between different mitochondrial subpopulations