Evaluation of the needle technique for producing an arteriovenous fistula.
Evaluation of the needle technique for producing an arteriovenous fistula.
复制标题
评估动静脉瘘针技术。
DOI：
10.1152/jappl.1994.77.6.2907
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Hester,RL
中科院分区：
文献类型：
--
作者：
Huang,M;LeBlanc,MH;Hester,RL
本研究的目的是评价建立动静脉（a-v）瘘的针刺技术，并定量测定具有三种不同瘘尺寸的大鼠的血流动力学反应。在雄性Sprague-Dawley大鼠中，通过使用20-、18-和16-号血管针在肾动脉下方的主动脉和腔静脉之间制作瘘。在假手术或建立动静脉瘘后5周，定量测定平均动脉压（MAP）、右心房压、分流流量、心脏指数、体循环流量、单个器官流量和心脏重量。所有流量测量均使用放射性微球进行。肺的流量被用作分流流量的测量。20、18和16 G瘘管动物的分流流量分别从总心输出量的2 +/- 1%（SE）显著增加至50.0 +/- 0.1、78 +/- 3和76 +/- 3%。与对照组相比，20、18和16号瘘管动物的平均心脏指数分别增加了105、270和250%。右心房压力和心脏重量与瘘管大小成比例增加。对照组和20、18和16号瘘管动物的MAP分别为122 +/- 5、126 +/- 3、118 +/- 3和111 +/- 4 mmHg。这些组中的任何一组之间的MAP或体循环流量均无显著差异。与对照组相比，所有瘘管组的计算总外周阻力均显著降低。（250字处删节）
The purpose of the present study were to evaluate the needle technique of creating an arteriovenous (a-v) fistula and to quantitatively determine the hemodynamic responses in rats with three different fistula sizes. The fistula was made in male Sprague-Dawley rats between the aorta and vena cava below the renal arteries by using 20-, 18-, and 16-gauge angiocath needles. Five weeks after a sham operation or creation of an a-v fistula, mean arterial blood pressure (MAP), right atrial pressure, shunt flow, cardiac index, systemic flow, individual organ flows, and heart weight were quantitatively determined. All flow measurements were made using radioactive microspheres. The flow to the lungs was used as a measure of shunt flow. The shunt flow in the 20-, 18-, and 16-gauge fistula animals was significantly increased from a value of 2 +/- 1% (SE) to 50.0 +/- 0.1, 78 +/- 3, and 76 +/- 3% of total cardiac output, respectively. Average cardiac index in the 20-, 18-, and 16-gauge fistula animals increased by 105, 270, and 250%, respectively, compared with control. Right atrial pressure and heart weight were increased in proportion to the size of the fistula. MAP in the control and 20-, 18-, and 16-gauge fistula animals was 122 +/- 5, 126 +/- 3, 118 +/- 3, and 111 +/- 4 mmHg, respectively. There were no significant differences in MAP or systemic flow among any of these groups. The calculated total peripheral resistance in all fistula groups was significantly decreased compared with control.(ABSTRACT TRUNCATED AT 250 WORDS)