VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathology
VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathology
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DOI：
10.1016/s1286-4579(02)01617-9
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发表时间：
2002-07-01
影响因子：
5.8
通讯作者：
De Baetselier, P
中科院分区：
文献类型：
--
作者：
Magez, S;Stijlemans, B;De Baetselier, P
非洲锥虫表达一种糖基磷脂酰肌醇（GPI）锚定的变异体特异性表面糖蛋白（VSG）作为保护膜。在感染期间，大量的VSG分子被释放到血液循环中。它们与免疫系统的各种细胞相互作用是严重感染相关病理的基础。最近的研究结果表明，接种抗gpi疫苗可以预防这种病理的发生。(C) 2002年版《科学与医学》Elsevier SAS。版权所有。
African trypanosomes express a glycosylphosphatidyl inositol (GPI)-anchored variant-specific surface glycoprotein (VSG) as a protective coat. During infection, large amounts of VSG molecules are released into the circulation. Their interaction with various cells of the immune system underlies the severe infection-associated pathology. Recent results have shown that anti-GPI vaccination can prevent the occurrence of this pathology. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.