Leptin, but not adiponectin, predicts stroke in males
Leptin, but not adiponectin, predicts stroke in males
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DOI：
10.1111/j.1365-2796.2004.01351.x
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发表时间：
2004-08-01
影响因子：
11.1
通讯作者：
Olsson, T
中科院分区：
文献类型：
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作者：
Söderberg, S;Stegmayr, B;Olsson, T
Objective.为了检验瘦素和脂联素是否是首次卒中的危险标志物。研究设计、方法和受试者。一项巢式病例参照研究确定了276例首次卒中病例（234例缺血性卒中和42例出血性卒中）。在中风之前，他们参加了瑞典北方的基于人群的健康调查（调查和中风之间的中位时间为4.9年）。参考者的性别、年龄、健康调查的日期和类型以及地理区域都是匹配的。采用条件Logistic回归分析首次卒中的假定危险标志物，包括血压（BP）、糖尿病、吸烟、体重指数（BMI）、胆固醇、瘦素和脂联素。在未来的卒中患者中发现BMI增加、高胆固醇和空腹血糖水平、糖尿病和高血压。而瘦素水平较高的男性受试者（P = 0.004），脂联素没有组间差异。高瘦素水平独立预测男性中风（OR = 2.46; 95%CI 1.08-5.62），但在女性中没有。脂联素水平不能预测中风。高瘦素水平的男性比低瘦素水平的男性更快发生卒中（P = 0.0009），与传统的危险因素无关。瘦素可能是男性脑血管疾病发展的重要环节，而脂联素与未来卒中无关。
Objective. To test whether leptin and adiponectin are risk markers for a first-ever stroke.Research design, methods and subjects. A nested case-referent study identified 276 cases with first-ever stroke (234 cases with ischaemic and 42 with haemorrhagic stroke). Prior to the stroke, they had participated in population-based health surveys in northern Sweden (median time between survey and stroke was 4.9 years). Referents were matched for sex, age, date and type of health survey, and geographical region. Putative risk markers for first-ever stroke, including blood pressure (BP), diabetes, smoking, body mass index (BMI), cholesterol, leptin, and adiponectin, were analysed by conditional logistic regression analysis.Results. Increased BMI, high cholesterol and fasting glucose levels, diabetes mellitus and hypertension were found in future stroke patients. Whereas leptin levels were higher in male subjects (P = 0.004), adiponectin did not differ between groups. A high leptin level independently predicted stroke in men (OR = 2.46; 95% CI 1.08-5.62) but not in women. Adiponectin levels did not predict stroke. Males with high leptin levels developed stroke faster than males with low leptin levels (P = 0.0009), independently of traditional risk factors.Conclusions. Leptin may be an important link to the development of cerebrovascular disease in men, whereas adiponectin does not associate with future stroke.