ERG11 Gene Mutations and MDR1 Upregulation Confer Pan-Azole Resistance in Candida tropicalis Causing Disseminated Candidiasis in an Acute Lymphoblastic Leukemia Patient on Posaconazole Prophylaxis.
ERG11 Gene Mutations and MDR1 Upregulation Confer Pan-Azole Resistance in Candida tropicalis Causing Disseminated Candidiasis in an Acute Lymphoblastic Leukemia Patient on Posaconazole Prophylaxis.
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ERG11 基因突变和 MDR1 上调导致热带念珠菌对泛唑耐药，导致接受泊沙康唑预防的急性淋巴细胞白血病患者出现播散性念珠菌病
DOI：
10.1128/aac.02496-16
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发表时间：
2017-07
影响因子：
4.9
通讯作者：
Meng H
中科院分区：
文献类型：
--
作者：
You L;Qian W;Yang Q;Mao L;Zhu L;Huang X;Jin J;Meng H
摘要在这项研究中，我们提出了一个罕见的情况下，致命的突破热带念珠菌感染的急性淋巴细胞白血病（ALL）患者，而泊沙康唑预防。然后，我们探讨唑类耐药的机制，重点是增强外排泵和唑类靶酶Erg11 p的变化，这是由ERG11基因编码。我们的研究表明，Y132C替代Erg11p结合MDR1过表达可能是泛唑耐药机制热带念珠菌。
ABSTRACT In this study, we present a rare case of fatal breakthrough Candida tropicalis infection in a patient with acute lymphoblastic leukemia (ALL) while on posaconazole prophylaxis. Then, we explore the mechanisms underlying azole resistance by focusing on enhanced efflux pumps and changes in the azole target enzyme Erg11p, which was encoded by the ERG11 gene. Our study demonstrates that Y132C substitution of Erg11p combined with MDR1 overexpression may be the pan-azole resistance mechanisms in Candida tropicalis.