SPLENIC HOMOTRANSPLANTATION *
SPLENIC HOMOTRANSPLANTATION *
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脾同种移植*
DOI：
10.1111/j.1749-6632.1965.tb30689.x
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发表时间：
1965
影响因子：
5.2
通讯作者：
H. Fudenberg
中科院分区：
文献类型：
--
作者：
T. Marchioro;D. Rowlands;D. Rifkind;W. Waddell;T. Starzl;H. Fudenberg
在过去的12个月里，为了给受者提供活跃的免疫组织，我们进行了5例临床全器官同种异体脾移植。在一例低丙种球蛋白血症的病例中，移植的组织有望缓解免疫缺陷的状态。在其他四人中，他们都患有晚期恶性肿瘤，目的是将一种改变的免疫反应状态叠加到宿主身上，希望借此抑制肿瘤的不可阻挡的生长。如下所述，现在可以判断这些程序在每个情况下都是没有益处的。然而，完整的病例记录似乎是合理的，不仅因为移植具有免疫能力的组织的许多含义，而且还因为在这些患者的护理过程中所做的潜在的重要观察。此外，还将全面介绍支持同种异体脾移植的犬的研究，以及许多临床治疗和研究的原则，这些原则是从先前对狗的观察得出的。事实上，在狗身上可以获得长达一年三分之二的同种异体脾移植，而不会产生侏儒疾病或其他有害影响，这一事实可能会在未来对骨髓、其他淋巴系或同种肝移植的研究中应用。
During the past 12 months, five clinical whole-organ splenic homotransplantations have been carried out with the objective of providing active immunologic tissue for the recipient patients. In one case with hypogammaglobulinemia, it was hoped that the transplanted tissue would alleviate a state of immunologic deficiency. In the other four, all of whom had terminal malignancies, the purpose was to superimpose a state of altered immunologic reactivity upon the host in the hope of thereby suppressing the inexorable growth of the neoplasms. As will be described, these procedures can now be judged in each instance to have been without benefit. Nevertheless, full documentation of the cases seems justified not only because of the many implications of transplantation of immunologically competent tissue, but also because of the potentially important observations made during the care of these patients. In addition, a full account will be presented of the supporting canine studies of splenic homotransplantalion, inasmuch as many of the principles of clinical therapy and investigation derived from prior observations in the dog. The fact that it is possible to obtain viable splenic homografts in the dog for as long as two-thirds of a year without the production of runt disease or other harmful effects may have application in future research on bone marrow, other lymphoid, or hepatic homografts.