Endometrial leukocytes and menstruation
Endometrial leukocytes and menstruation
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DOI：
10.1093/humupd/6.1.16
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发表时间：
2000-01-01
影响因子：
13.3
通讯作者：
Lathbury, LJ
中科院分区：
文献类型：
--
作者：
Salamonsen, LA;Lathbury, LJ
本文综述了支持这一概念的证据，即月经发生的炎症过程的结果，在子宫内膜，白细胞数量上升，在分泌后期血清孕酮浓度下降。据推测，这些白细胞激活后释放的产物对月经至关重要。肥大细胞、嗜酸性粒细胞、嗜中性粒细胞和巨噬细胞尤其涉及。子宫内膜颗粒淋巴细胞也可能起作用，尽管它们的数量在月经周期中的增加比其他细胞的增加要早一些，这表明它们可能在胚胎着床中起主要作用。白细胞产物包括一系列蛋白酶、趋化因子和细胞因子，它们共同导致子宫内膜细胞局灶性产生和激活基质金属蛋白酶，以及随后的组织分解，这是月经的特征。子宫内膜内白细胞进入、增殖、分化和活化的调节尚未被很好地理解，尽管子宫内膜细胞局部产生的趋化因子和细胞因子都明确涉及。虽然子宫内膜白细胞上孕激素受体的缺乏提示了孕激素的间接作用，但孕激素在调节这些事件中的作用仍不清楚。
This review examines evidence supporting the concept that menstruation occurs as a result of an inflammatory process, In the endometrium, leukocyte numbers rise in the late secretory phase following the fall in serum progesterone concentrations. It is postulated that products released following activation of these leukocytes are critically important for menstruation. Mast cells, eosinophils, neutrophils and macrophages in particular are involved. Endometrial granular lymphocytes may also play a role, although their increase in numbers is somewhat earlier during the menstrual cycle than that of the others, suggesting perhaps a primary role in embryo implantation. Leukocyte products include a range of proteases, chemokines and cytokines which in concert result in focal production and activation of matrix metalloproteinases by endometrial cells and the subsequent breakdown of tissue that characterizes menstruation. Regulation of leukocyte entry, proliferation, differentiation and activation within the endometrium is not Set well understood, although both chemokines and cytokines produced locally by endometrial cells are clearly implicated. The role of progesterone in regulating these events is still not understood although the lack of progesterone receptors on endometrial leukocytes suggests indirect actions.