Synthesis and characterization of novel calcium phosphate glass-derived cements for vital pulp therapy
Synthesis and characterization of novel calcium phosphate glass-derived cements for vital pulp therapy
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DOI：
10.1007/s10856-019-6352-5
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发表时间：
2020-01-02
影响因子：
3.7
通讯作者：
Carlson, Krista
中科院分区：
文献类型：
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作者：
Howard, Jerry;Gardner, Levi;Carlson, Krista
利用偏硅酸钠（NaSi）玻璃独特的腐蚀性能，评价新型无机盖髓水泥的物理化学行为和固化反应。采用熔融急冷法合成了NaSi和CaP玻璃粉。通过将不同量的玻璃与去离子水以2.5 g/mL（-1）的粉液比混合来产生水泥。使用压痕标准ISO 9917-1测量工作时间和凝固时间。通过将每种组合物的设定样品放置在亚甲蓝染料溶液中24小时来测试密封能力。还将组样品浸没在磷酸盐缓冲盐水中，并在37 ℃下孵育一周。孵育后使用X射线衍射来鉴定成熟的晶相。红外光谱和扫描电子显微镜被用来表征水泥之前，之后设置和孵育后。测量的工作和凝固时间分别在2-5和10- 2 - 5 min范围内。工作时间和凝结时间一般随NaSi浓度的增加而减小。发现具有25和33重量% NaSi的组合物的水泥抵抗染料的渗透并保持其形状。在该范围之外的组合物吸收染料并塌陷。红外光谱提供了深入了解这些水泥的设置机制。在体外一周后，发现水泥含有与化学稳定的生物活性相匹配的结晶相。NaSi和CaP玻璃的组合具有有利的凝固行为、密封能力和用于盖髓的成熟阶段，同时依赖于相对简单的无机组合物。
Evaluation of the physicochemical behavior and setting reactions of a novel inorganic pulp capping cement which makes use of the unique corrosion properties of sodium metasilicate (NaSi) glass. NaSi and calcium phosphate (CaP) glass powders were synthesized through a melt-quench method. Cements were created by mixing various amounts of the glasses with deionized water at a powder-to-liquid ratio of 2.5 g mL(-1). Working and setting times were measured using the indentation standard ISO 9917-1. Sealing ability was tested by placing set samples of each composition in methylene blue dye solution for 24 h. Set samples were also submerged in phosphate buffered saline and incubated at 37 degrees C for one week. X-ray diffraction was used to identify mature crystalline phases after incubation. Infrared spectroscopy and scanning electron microscopy were used to characterize cements before and after setting and after incubation. Working and setting times measured in the ranges of 2-5 and 10-25 min, respectively. Working and setting time generally decrease with increased NaSi concentration. Cements with compositions of 25 and 33 wt% NaSi were found to resist the infiltration of dye and maintain their shape. Compositions outside this range absorbed dye and collapsed. Infrared spectroscopy provided insight into the setting mechanism of these cements. After one week in vitro, cements were found to contain crystalline phases matching chemically stable, bioactive phases. The combination of NaSi and CaP glasses has favorable setting behavior, sealing ability, and mature phases for pulp capping while relying on a relatively simple, inorganic composition.