Sleep deprivation in the rat: IX. Recovery.
Sleep deprivation in the rat: IX. Recovery.
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DOI：
10.1093/sleep/12.1.60
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发表时间：
1989
期刊：
影响因子：
5.6
通讯作者：
C. Everson;M. Gilliland;C. Kushida;June J. Pilcher;Victor S. Fang;Samuel Refetoff;B. Bergmann;Allan Rechtschaffen
中科院分区：
文献类型：
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作者：
C. Everson;M. Gilliland;C. Kushida;June J. Pilcher;Victor S. Fang;Samuel Refetoff;B. Bergmann;Allan Rechtschaffen
8只大鼠进行完全睡眠剥夺，异相睡眠剥夺，或高振幅睡眠剥夺，直到他们表现出重大剥夺诱导的变化。然后他们被允许随意睡觉。三只表现出最大温度下降的大鼠在两到六天的恢复期内死亡。在自由睡眠的前15天，存活大鼠表现出完全或几乎完全逆转以下剥夺诱导的变化：虚弱的外观，爪子和尾巴上的病变，高能量消耗，腹膜温度大幅下降，高血浆肾上腺素和去甲肾上腺素水平，和低甲状腺素水平。所有大鼠恢复睡眠的最显著特征是异相睡眠立即大幅反弹至远高于基线水平，其次是短暂延长的反弹。高振幅非快速眼动（NREM）睡眠的反弹只发生在一些大鼠中，并且较小且不那么即时。
Eight rats were subjected to total sleep deprivation, paradoxical sleep deprivation, or high amplitude sleep deprivation until they showed major deprivation-induced changes. Then they were allowed to sleep ad lib. Three rats that had shown the largest temperature declines died within two to six recovery days. During the first 15 days of ad lib sleep, surviving rats showed complete or almost complete reversal of the following deprivation-induced changes: debilitated appearance, lesions on the paws and tail, high energy expenditure, large decreases in peritoneal temperature, high plasma epinephrine and norepinephrine levels, and low thyroxine levels. The most prominent features of recovery sleep in all rats were immediate and large rebounds of paradoxical sleep to far above baseline levels, followed by lesser temporally extended rebounds. Rebounds of high amplitude non-rapid eye movement (NREM) sleep occurred only in some rats and were smaller and less immediate.