On Verbal/Nonverbal Modality Dependence of Left and Right Inferior Prefrontal Activation during Performance of Flanker Interference Task
On Verbal/Nonverbal Modality Dependence of Left and Right Inferior Prefrontal Activation during Performance of Flanker Interference Task
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DOI：
10.1162/jocn.2008.20138
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发表时间：
2008-11-01
影响因子：
3.2
通讯作者：
Konishi, Seiki
中科院分区：
文献类型：
--
作者：
Morimoto, Hiroki M.;Hirose, Satoshi;Konishi, Seiki
关于人类认知功能定位的最流行的观点之一是半球专业化，其中左半球和右半球主要涉及语言和非语言功能。认知控制涉及外侧前额皮质。然而，目前尚不清楚是否可以在独立于刺激材料的感觉方面的认知控制中观察到外侧前额叶皮层的半球特化。在这项功能性磁共振成像研究中，我们通过研究干扰抑制（过滤掉环境中不相关信息的能力）来测试语言/非语言半球特化是否适用于外侧前额叶激活。侧翼任务采用包含目标和侧翼的复合刺激。侧翼刺激可以是一个颜色单词旁边有一个彩色的小块，也可以是一个彩色的小块旁边有一个颜色的小块，这样我们就可以操纵来自干扰的侧翼刺激的模态，从而保持整个刺激模态的平衡。下额回（IFG）在干扰抑制中表现出明显的模态-半球相互作用，左侧IFG在单词侧链（加上一个小块目标）出现时被激活，右侧IFG在一个小块侧链（加上一个单词目标）出现时被激活。这些结果表明，IFG中的言语/非言语半球特化可以用认知控制过程本身来解释，而不依赖于所呈现材料的感官方面。
One of the most prevailing views on the functional localization of human cognition is the hemispheric specialization, wherein the left and right hemispheres are implicated primarily in verbal and nonverbal functions, respectively. Cognitive control is known to involve the lateral prefrontal cortex. However, it remains unclear whether the hemispheric specialization in the lateral prefrontal cortex can be observed in cognitive control per se, independent of sensory aspects of stimulus materials. In this functional magnetic resonance imaging study, we tested whether the verbal/nonverbal hemispheric specialization applies to the lateral prefrontal activation by investigating interference suppression, the ability to filter out irrelevant information in the environment. The flanker task was employed using a compound stimulus that contained a target and a flanker. The flanked stimulus was either a color word flanked by a colored patch or a colored patch flanked by a color word, which allowed us to manipulate the modality of the presented flanker stimulus from which interference originates, keeping the total stimulus modality balanced. The inferior frontal gyrus (IFG) showed prominent Modality-by-Hemisphere interaction in interference suppression, the left IFG being activated when a word flanker (plus a patch target) was presented and the right IFG being activated when a patch flanker (plus a word target) was presented. These results suggest that the verbal/nonverbal hemispheric specialization in the IFG can be explained by cognitive control processes per se, independent of sensory aspects of presented materials.