Local production of broadly cross‐reactiveIgE against multiple fungal cell wall polysaccharides in patients with allergic fungal rhinosinusitis
Local production of broadly cross‐reactiveIgE against multiple fungal cell wall polysaccharides in patients with allergic fungal rhinosinusitis
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过敏性真菌性鼻窦炎患者局部产生针对多种真菌细胞壁多糖的广泛交叉反应性 IgE
DOI：
10.1111/all.15413
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发表时间：
2022
期刊：
影响因子：
12.4
通讯作者：
Sakakibara Shuhei
中科院分区：
文献类型：
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作者：
Haruna Soichiro;Takeda Kazuya;El‐Hussien Marwa Ali;Maeda Yohei;Hayama Masaki;Shikina Takashi;Doi Katsumi;Inohara Hidenori;Kikutani Hitoshi;Sakakibara Shuhei
在我们的队列中，AFRS患者的血清抗真菌IgE和IgG滴度高于嗜酸性粒细胞性慢性鼻窦炎伴鼻息肉（eCRSwNP）患者和健康个体（图S1 A、B和表S1）。为了解决这些问题，我们从AFRS患者鼻息肉中分泌IgE的浆母细胞（PB）产生单克隆抗体（mAb），并表征其抗原反应性。变应性真菌性鼻窦炎（AFRS）是以真菌过敏为特征的慢性鼻窦炎的一个亚类。1 AFRS患者的血清IgE通常对多种真菌表现出广泛的反应性，包括I Alternaria alternata i和I Aspergillus fumigatus i 2。[摘自文章]过敏的版权是威利-布莱克威尔的财产，其内容不得复制或通过电子邮件发送到多个网站或张贴到一个列表服务器未经版权保持器的明确书面许可。但是，用户可以打印，下载或电子邮件的文章供个人使用。这篇摘要可以删节。不保证副本的准确性。用户应参考原始出版版本的材料的完整摘要。版权适用于所有摘要。
In our cohort, AFRS patients had higher serum antifungal IgE and IgG titers than patients with eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) and healthy individuals (Figure S1A, B and Table S1). To address these questions, we generated monoclonal Abs (mAbs) from IgE-secreting plasmablasts (PBs) in the nasal polyps of patients with AFRS and characterized their antigen reactivity. Allergic fungal rhinosinusitis (AFRS) is a subset of chronic rhinosinusitis characterized by fungal allergy. 1 Serum IgE of AFRS patients often exhibits broad reactivity to multiple fungi, including I Alternaria alternata i and I Aspergillus fumigatus i 2.[Extracted from the article]Copyright of Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.