Bone ingrowth into two porous ceramics with different pore sizes: an experimental study.
Bone ingrowth into two porous ceramics with different pore sizes: an experimental study.
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发表时间：
2004-12
影响因子：
0.4
通讯作者：
L. Galois;D. Mainard
中科院分区：
文献类型：
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作者：
L. Galois;D. Mainard
多孔磷酸钙陶瓷的许多性能已被描述，但孔径如何影响各种多孔陶瓷的骨整合仍不清楚。本研究旨在量化两种多孔磷酸钙陶瓷的骨长入和生物降解性，这两种多孔磷酸钙陶瓷具有四种不同的孔径范围（45-80 μ m、80-140 μ m、140-200 μ m和200-250 μ m）。将羟基磷灰石（HA）和β-磷酸三钙（TCP）圆柱体植入家兔股骨髁，并原位放置长达12个月。测定骨长入的百分比和孔内的长入深度。还评价了植入物的生物降解性。在相同孔径范围内，TCP的骨长入速率高于HA陶瓷。无论HA的植入时间如何，TCP的植入时间为4个月，45-80 μ m孔径的陶瓷中新形成的骨的量在统计学上小于（p < 0.05）较大孔径的陶瓷。在三个最高孔径范围之间未观察到统计学差异。长达4个月未观察到植入物降解。我们的研究结果表明，在HA和TCP陶瓷中，大于80微米的孔径可以改善骨长入。TCP中的骨形成高于HA种植体。
Many properties of porous calcium phosphate ceramics have been described, but how pore size influences bony integration of various porous ceramics remains unclear. This study was performed to quantify the bony ingrowth and biodegradability of two porous calcium phosphate ceramics with four different pore size ranges (45-80 microm, 80-140 microm, 140-200 microm, and 200-250 microm). Hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) cylinders were implanted into the femoral condyles of rabbits and were left in situ for up to 12 months. The percentage of bone ingrowth and the depth of ingrowth within the pores were determined. Biodegradability of the implants was also evaluated. Bone ingrowth occurred at a higher rate into the TCP than into the HA ceramics with the same pore size ranges. The amount of newly formed bone was statistically smaller (p < 0.05) into ceramics with 45-80 microm pore size than with larger pore size, whatever the implantation time for HA and until four months for TCP. No statistical difference was noted between the three highest pore size ranges. No implant degradation was noted up to four months. Our results suggest that a pore size above 80 microm improves bony ingrowth in both HA and TCP ceramics. Bone formation was higher in the TCP than in the HA implants.