Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases.
Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases.
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DOI：
10.1186/s40413-016-0094-3
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Triggiani M
中科院分区：
文献类型：
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作者：
Metcalfe DD;Pawankar R;Ackerman SJ;Akin C;Clayton F;Falcone FH;Gleich GJ;Irani AM;Johansson MW;Klion AD;Leiferman KM;Levi-Schaffer F;Nilsson G;Okayama Y;Prussin C;Schroeder JT;Schwartz LB;Simon HU;Walls AF;Triggiani M
疾病活动的生物标志物已广泛用于人类疾病机制的研究和临床医学中，以诊断和预测疾病进程;以及监测对治疗干预的反应。在这里，我们回顾了肥大细胞，嗜碱性粒细胞和嗜酸性粒细胞在人类过敏性炎症的参与生物标志物。包括细胞活化的表面标志物以及这些炎症细胞的特定产物，这些产物表明炎症过程中的特定细胞类型，并且在临床研究以及过敏免疫学实践中做出的决策中可能具有价值。
Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic intervention. Here we review biomarkers of the involvement of mast cells, basophils, and eosinophils in human allergic inflammation. Included are surface markers of cell activation as well as specific products of these inflammatory cells that implicate specific cell types in the inflammatory process and are of possible value in clinical research as well as within decisions made in the practice of allergy-immunology.