Polycomblike: a gene that appears to be required for the normal expression of the bithorax and antennapedia gene complexes of Drosophila melanogaster.
Polycomblike: a gene that appears to be required for the normal expression of the bithorax and antennapedia gene complexes of Drosophila melanogaster.
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DOI：
10.1093/genetics/102.1.49
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发表时间：
1982-09
期刊：
影响因子：
3.3
通讯作者：
I. Duncan
中科院分区：
文献类型：
--
作者：
I. Duncan
一种新发现的基因被描述为在苍蝇的许多身体部分中维持正常身份所必需的。该基因被称为Polycomblike (Pcl)，其突变体的影响表明其野生型等位基因在双胸基因复合体（BX-C）和天线基因复合体（ANT-C）的调控中起作用。支持这一观点的证据来自(1)Pcl突变体引起的片段转化与BX-C和ANT-C中显性功能获得突变体引起的片段转化之间的密切对应，(2)Pcl突变体与这些复合物中突变体之间观察到的相互作用，以及(3)Pcl突变体引起的至少一种转化的严重程度依赖于BX-C和ANT-C的剂量。提出了Pcl+对BX-C和ANT-C的控制本质上是负的。克隆分析实验结果表明，至少对BX-C来说，Pcl+直到发育后期才发挥这种控制作用。由于另一种称为Polycomb （Pc）的基因的野生型等位基因先前已被证明具有许多与Pcl+相同的特性，因此BX-C和ANT-C似乎在发育过程中受到至少两个甚至几个其他基因的持续调节。
A newly identified gene is described that is required for the maintenance of normal identities in many of the body segments of the fly. The effects of mutants in this gene, which is called Polycomblike (Pcl), suggest that its wild-type allele functions in the regulation of the bithorax gene complex (BX-C) and the Antennapedia gene complex (ANT-C). Evidence in favor of this idea derives from (1) the close correspondence between segmental transformations caused by Pcl mutants and those caused by dominant gain-of-function mutants in the BX-C and ANT-C, (2) the interactions observed between Pcl mutants and mutants in these complexes, and (3) the dependence upon BX-C and ANT-C dosage of the severity of at least one of the transformations caused by Pcl mutants. Arguments are presented that the control of the BX-C and ANT-C by Pcl+ is negative in nature. The results of clonal analysis experiments indicate that, at least for the BX-C, Pcl+ exerts this control until late in development. Since the wild-type allele of another gene, called Polycomb (Pc), has previously been shown to have many of the same properties as Pcl+, it appears that the BX-C and perhaps also the ANT-C are continuously regulated during development by at least two and probably several other genes.