Inhibitory mechanism of lycopene on cytokine expression in experimental pancreatitis
Inhibitory mechanism of lycopene on cytokine expression in experimental pancreatitis
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DOI：
10.1111/j.1749-6632.2011.06107.x
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Kim, Hyeyoung
中科院分区：
文献类型：
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作者：
Kim, Hyeyoung
Reactive oxygen species (ROS) are important mediators to induce pancreatitis. Serum levels of antioxidant enzymes and carotenoids including lycopene are lower in patients with pancreatitis than those of healthy subjects. The cholecystokinin (CCK) analog cerulcin induces similar pathologic events as shown in human pancreatitis. Recent studies show that high doses of cerulein activate NF-kappa B and induce the expression of inflammatory cytokines, in pancreatic acinar cells, which is mediated by the activation of NADPH oxidase. Lycopene functions as a very potent antioxidant to suppress the induction of inflammatory cytokines, in pancreatic acinar cells stimulated with cerulein. In this review, the possible beneficial effect of lycopene on experimental pancreatitis shall be discussed based on its antioxidant activity.
