Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019
Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019
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DOI：
10.1128/aac.02718-20
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发表时间：
2021-06-01
影响因子：
4.9
通讯作者：
Xavier Lopez-Labrador, F.
中科院分区：
文献类型：
--
作者：
Mengual-Chulia, Beatriz;Alonso-Cordero, Andres;Xavier Lopez-Labrador, F.
采用全基因组测序技术监测流行甲型流感病毒对三种聚合酶复合物抑制剂的易感性。在分析的285个基因组中，共发现12个抗性替换，但没有一个与高抗性相关。对这些甲型流感抗病毒药物的自然耐药性目前并不常见。
Molecular surveillance by whole-genome sequencing was used to monitor the susceptibility of circulating influenza A viruses to three polymerase complex inhibitors. A total of 12 resistance substitutions were found among 285 genomes analyzed, but none were associated with high levels of resistance. Natural resistance to these influenza A antivirals is currently uncommon.