Metabolic reprograming of cancer as a therapeutic target.
Metabolic reprograming of cancer as a therapeutic target.
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DOI：
10.1016/j.bbagen.2022.130301
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发表时间：
2022-12
期刊：
影响因子：
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通讯作者：
T. Furukawa;Sho Tabata;Kentaro Minami;Masatatsu Yamamoto;K. Kawahara;A. Tanimoto
中科院分区：
文献类型：
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作者：
T. Furukawa;Sho Tabata;Kentaro Minami;Masatatsu Yamamoto;K. Kawahara;A. Tanimoto
随着代谢组学分析技术的进步，我们对癌症中代谢重编程的理解沿着有了巨大的提高。癌细胞的代谢变化被证明比经典的瓦尔堡效应复杂得多。以前的研究已经接近代谢变化作为治疗和/或化学预防的目标。最近，一些临床试验报道了与代谢相关的抗癌药物。然而，癌细胞是否依赖于代谢重编程或有利于合适的条件仍然不清楚。这两种情况可能相互交织。识别下游分子和理解重编程代谢的机制可以提高癌症治疗的有效性。在这里，我们回顾了癌细胞的代谢重编程和靶向代谢相关分子的治疗的几个例子，并讨论了改善下一代癌症治疗的实用方法，重点是癌症的代谢重编程。
Our understanding of metabolic reprogramming in cancer has tremendously improved along with the technical progression of metabolomic analysis. Metabolic changes in cancer cells proved much more complicated than the classical Warburg effect. Previous studies have approached metabolic changes as therapeutic and/or chemopreventive targets. Recently, several clinical trials have reported anti-cancer agents associated with metabolism. However, whether cancer cells are dependent on metabolic reprogramming or favor suitable conditions remains nebulous. Both scenarios are possibly intertwined. Identification of downstream molecules and the understanding of mechanisms underlying reprogrammed metabolism can improve the effectiveness of cancer therapy. Here, we review several examples of the metabolic reprogramming of cancer cells and the therapies targeting the metabolism-related molecules as well as discuss practical approaches to improve the next generation of cancer therapies focused on the metabolic reprogramming of cancer.