Prion Strains and Transmission Barrier Phenomena.
Prion Strains and Transmission Barrier Phenomena.
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DOI：
10.3390/pathogens7010005
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发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Sibille P
中科院分区：
文献类型：
--
作者：
Igel-Egalon A;Béringue V;Rezaei H;Sibille P
许多实验证据表明，朊病毒是一种非常规的病原体，它的物理支持只包括蛋白质。这一发现提出了关于所观察到的朊病毒株间变异和物种屏障的问题，在过去的30年里，物种屏障碰巧对人类健康和兽医政策产生了巨大的影响。本文综述了朊病毒结构和朊病毒菌株表征领域的一些进展：从历史的方法，使朊病毒菌株的概念出现，最后的结果表明，朊病毒菌株可能实际上是一个组合的几个准物种与微妙的生物物理特性。然后，我们将集中在目前的知识，影响物种屏障强度和物种屏障跨越的因素。最后，我们提出了可能的情况下，如何应变性能与主机特性的相互作用可能会占新的构象异构体变体的差异选择，并最终跨越物种屏障。
Several experimental evidences show that prions are non-conventional pathogens, which physical support consists only in proteins. This finding raised questions regarding the observed prion strain-to-strain variations and the species barrier that happened to be crossed with dramatic consequences on human health and veterinary policies during the last 3 decades. This review presents a focus on a few advances in the field of prion structure and prion strains characterization: from the historical approaches that allowed the concept of prion strains to emerge, to the last results demonstrating that a prion strain may in fact be a combination of a few quasi species with subtle biophysical specificities. Then, we will focus on the current knowledge on the factors that impact species barrier strength and species barrier crossing. Finally, we present probable scenarios on how the interaction of strain properties with host characteristics may account for differential selection of new conformer variants and eventually species barrier crossing.
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影响因子：
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作者：
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通讯作者：
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