Update on bacterial conjunctivitis in south Florida
Update on bacterial conjunctivitis in south Florida
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DOI：
10.1016/j.ophtha.2007.03.076
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发表时间：
2008-01-01
期刊：
影响因子：
13.7
通讯作者：
Feuer, William
中科院分区：
文献类型：
--
作者：
Cavuoto, Kara;Zutshi, Deepti;Feuer, William
目的：报告1994年至2003年在佛罗里达迈阿密的巴斯科姆帕尔默眼科研究所进行的细菌性结膜炎患者的人口统计学、微生物发生率和体外耐药趋势。设计：回顾性横断面研究。参与者：2408只眼睛。方法：从1994年1月1日到12月31日，在巴斯科姆帕尔默眼科研究所寻求治疗的所有细菌性结膜炎患者的微生物学记录，2003年进行了审查。收集年龄、性别、培养阳性趋势和体外敏感性数据。使用光盘扩散和最小抑菌concentrations.Main Outcome Measures：阳性培养年龄，性别，和生物体和体外resistance.Results：在10年期间，1254培养阳性病原体被回收2408连续结膜拭子（52.1%）。1994 ~ 1998年培养阳性率为55%，后5年下降到44%。男性和女性患者占总分离株的百分比相同（50.0%）。女性革兰氏阳性菌的百分比高于男性（55.5%; P = 0.033）。革兰阳性菌占培养阳性菌的52.2%。金黄色葡萄球菌是总体（37.6%）和6岁以上患者（47.8%）中最常见的分离株。耐甲氧西林表皮葡萄金黄色葡萄球菌在10年内呈显著上升趋势（4.4%~ 42.9%）。金黄色葡萄球菌分离株; P = 0.001）。流感嗜血杆菌是7岁以下患者中最常见的分离株（59.8%; P = 0.0002）。革兰阳性菌对环丙沙星和苯唑西林的耐药性增加了3倍（P = 0.001）。总体而言，9.5%的革兰氏阳性分离株对庆大霉素耐药。革兰阴性菌对甲氧苄啶/磺胺的耐药性呈上升趋势（P = 0.05）。耐甲氧西林表皮葡萄金黄色葡萄球菌的患病率显著增加。革兰氏阳性菌对红霉素和环丙沙星的耐药性分别增加了2倍和3倍。庆大霉素对革兰氏阳性菌有较好的敏感性。眼科学2008;115：51-56（c）2008，美国眼科学会。
Purpose: To report demographics, organism occurrence, and in vitro resistance trends for patients presenting with bacterial conjunctivitis at Bascom Palmer Eye Institute in Miami, Florida from 1994 to 2003.Design: Retrospective cross-sectional study.Participants: Two thousand four hundred eight eyes.Methods: The microbiology records of all patients with bacterial conjunctivitis seeking treatment at Bascom Palmer Eye Institute from January 1, 1994 through December 31, 2003 were reviewed. Data on age, gender, culture-positive trends, and in vitro susceptibility were collected. In vitro susceptibility data were generated using disc diffusion and minimal inhibitory concentrations.Main Outcome Measures: Positive cultures by age, gender, and organism and in vitro resistance.Results: During the 10-year period, 1254 culture-positive pathogens were recovered from 2408 consecutive conjunctival swabs (52.1%). The culture-positive rate from 1994 to 1998 was 55% and declined to 44% in the second 5 years. Male and female patients contributed equal percentages to the total isolates (50.0%). Females had a higher percentage of gram-positives than males (55.5%; P = 0.033). Gram-positive pathogens accounted for 52.2% of culture positive isolates. Staphylococcus aureus was the most frequent isolate overall (37.6%) and in patients older than 6 years (47.8%). Methicillin-resistant S. aureus showed a significant increase in the 10-year period (4.4%-42.9% of S. aureus isolates; P = 0.001). Haemophilus influenzae was the most frequent isolate recovered from patients under 7 years old (59.8%; P = 0.0002). There was a 3-fold increase in resistance of gram-positives to ciprofloxacin and oxacillin (P = 0.001). Overall, 9.5% of gram-positive isolates were resistant to gentamicin. Trimethoprim/sulfa showed a steady increase in resistance in gram-negative isolates (P = 0.05).Conclusions: Staphylococcus aureus was the most common pathogen isolated. Methicillin-resistant S. aureus showed significant increasing prevalence. There were 2- and 3-fold increases in resistance of gram-positive organisms to erythromycin and ciprofloxacin, respectively. Gentamicin showed good sensitivity toward gram-positive pathogens. Ophthalmology 2008;115:51-56 (c) 2008 by the American Academy of Ophthalmology.