Evidence for Consolidation of Neuronal Assemblies after Seizures in Humans
Evidence for Consolidation of Neuronal Assemblies after Seizures in Humans
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DOI：
10.1523/jneurosci.3019-14.2015
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发表时间：
2015-01-21
影响因子：
5.3
通讯作者：
Worrell, Gregory A.
中科院分区：
文献类型：
--
作者：
Bower, Mark R.;Stead, Matt;Worrell, Gregory A.
记忆的建立涉及唤醒神经元活动模式的重新激活和慢波睡眠（SWS）期间相关神经回路的加强，这一过程被称为“细胞巩固”（Dudai和Morris，2013）。在数秒至数分钟的时间尺度上发生的清醒行为期间的神经活动模式的再激活被认为构成记忆回忆（O 'Keefe和Nadel，1978），而记忆痕迹的巩固可以通过在适于突触修饰的条件下在睡眠期间出现的相关放电（再激活）来揭示和服务（Buhry等人，2011年）。尽管在人类神经元记录中已经观察到再激活（Gelbard-Sagiv等人，2008;米勒等人，2013年），在睡眠中重新激活没有，可能是因为数据难以获得，效果很微妙。然而，癫痫发作提供强烈和同步的但稀疏的激活（Bower等人，2012年），如果癫痫发作激活了与学习相关的机制，类似于学习任务激活的机制，可能会产生更强的巩固效应。对接受颅内监测的耐药性癫痫患者进行连续宽带记录，发现在随后的SWS期间，与癫痫相关的神经元活动重新激活，但不清醒。那些在癫痫发作期间被最强烈地激活的神经元组件显示出最大的相关性变化，这表明巩固选择性地加强了癫痫发作激活的神经元回路。这些结果表明，癫痫发作“劫持”的生理学习机制，也提出了一种新的癫痫治疗癫痫发作后睡眠神经元动力学的目标。
The establishment of memories involves reactivation of waking neuronal activity patterns and strengthening of associated neural circuits during slow-wave sleep (SWS), a process known as "cellular consolidation" (Dudai and Morris, 2013). Reactivation of neural activity patterns during waking behaviors that occurs on a timescale of seconds to minutes is thought to constitute memory recall (O'Keefe and Nadel, 1978), whereas consolidation of memory traces may be revealed and served by correlated firing (reactivation) that appears during sleep under conditions suitable for synaptic modification (Buhry et al., 2011). Although reactivation has been observed in human neuronal recordings (Gelbard-Sagiv et al., 2008; Miller et al., 2013), reactivation during sleep has not, likely because data are difficult to obtain and the effect is subtle. Seizures, however, provide intense and synchronous, yet sparse activation (Bower et al., 2012) that could produce a stronger consolidation effect if seizures activate learning-related mechanisms similar to those activated by learned tasks. Continuous wide-bandwidth recordings from patients undergoing intracranial monitoring for drug-resistant epilepsy revealed reactivation of seizure-related neuronal activity during subsequent SWS, but not wakefulness. Those neuronal assemblies that were most strongly activated during seizures showed the largest correlation changes, suggesting that consolidation selectively strengthened neuronal circuits activated by seizures. These results suggest that seizures "hijack" physiological learning mechanisms and also suggest a novel epilepsy therapy targeting neuronal dynamics during post-seizure sleep.