The in vitro and in vivo uptake and metabolism of steroids in human adipose tissue.
The in vitro and in vivo uptake and metabolism of steroids in human adipose tissue.
复制标题
人体脂肪组织中类固醇的体外和体内摄取和代谢。
DOI：
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发表时间：
1974
影响因子：
5.8
通讯作者：
A. Chapdelaine
中科院分区：
文献类型：
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作者：
G. Bleau;K. Roberts;A. Chapdelaine
摘要脂肪组织中各种类固醇的摄取和代谢已经用体外和体内技术进行了研究。孕酮和睾酮的体外摄取（60%）被认为是远远高于皮质醇和雌三醇的摄取（13%）。在体内，总脂肪量对睾酮、雄烯二酮、雌酮和雌二醇的摄取在肥胖患者中比在非肥胖个体中大得多。雌酮和雌二醇与人脂肪组织切片孵育后可相互转化。在体外，孕酮代谢为多种化合物，20α-二氢孕酮4是主要代谢产物。在新生儿的棕色脂肪组织中，没有胆固醇或胆固醇硫酸盐转化为双烯醇酮或双烯醇酮硫酸盐。在成人皮下脂肪组织中，孕酮在体外没有转化为睾酮，雄烯二酮或14 C标记的睾酮也没有芳构化。
ABSTRACT The uptake and metabolism of various steroids in adipose tissue have been studied using both in vitro and in vivo techniques. The in vitro uptake of progesterone and testosterone (60%) was found to be much higher than the uptake of cortisol and estriol (13%). In vivo, the uptake of testosterone, androstenedione, estrone and estradiol by the total adipose mass was much greater in obese patients than in non obese individuals. Estrone and estradiol were found to be interconvertible following incubation with human adipose tissue slices. In vitro, progesterone was metabolized to a variety of compounds with 20α-dihydroprogesterone4 being the major metabolite. No conversion of cholesterol or cholesterol sulfate to pregnenolone or pregnenolone sulfate could be demonstrated in the brown adipose tissue of a newborn infant. In human adult subcutaneous adipose tissue, there was no in vitro conversion of progesterone to testosterone and no aromatization of androstenedione or testosterone labeled with 14C was ...