Application of classical gel electrophoresis to the chiral separation of milligram quantities of terbutaline.
Application of classical gel electrophoresis to the chiral separation of milligram quantities of terbutaline.
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DOI：
10.1021/ac970524q
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发表时间：
1998
影响因子：
7.4
通讯作者：
A. Stalcup;K. Gahm;S. R. Gratz;R. Sutton
中科院分区：
文献类型：
--
作者：
A. Stalcup;K. Gahm;S. R. Gratz;R. Sutton
虽然在过去的几十年里已经取得了巨大的进步，在能力做手性分离，做更大规模的手性分离的能力已经落后于目前的分析手性分离的最先进的状态。经典的凝胶电泳手性分离毫克量的手性物质的潜力进行检查。使用硫酸化环糊精作为手性添加剂的毫克量的特布他林的手性分离的协议被证明。该方法的可能的优点进行了讨论。
Although the last couple of decades has been tremendous progress in the ability to do chiral separations, the ability to do larger scale chiral separations has lagged somewhat behind the current analytical chiral separation state of the art. The potential of classical gel electrophoresis for chiral separation of milligram quantities of chiral material is examined. A protocol for the chiral separation of milligram quantities of terbutaline using sulfated cyclodextrin as a chiral additive is demonstrated. The possible advantages of the approach are discussed.