Natural Underwater Adhesives.
Natural Underwater Adhesives.
复制标题
DOI：
10.1002/polb.22256
复制
发表时间：
2011-06
影响因子：
--
通讯作者：
Hlady, Vladimir
中科院分区：
文献类型：
--
作者：
Stewart, Russell J.;Ransom, Todd C.;Hlady, Vladimir
本综述的总主题是由水生生物产生的蛋白质基水下粘合剂。重点是天然表面的界面粘合机制和天然水性粘合剂的受控水下固化。四个属，包括广泛的功能，一般的机械特征，和独特的适应性进行了详细讨论：蓝贻贝，橡子藤壶，沙堡蠕虫，和淡水石蛾幼虫。自然界中的水表面是带电的，并与其环境保持平衡，由双电层离子以及吸附的天然聚电解质和微生物生物膜填充。水下生物粘附剂的表面吸附可能通过氨基酸侧链交换表面结合的配体而发生，主要由聚合物官能团的相对亲和力和有效浓度驱动。大多数水生生物利用修饰的氨基酸侧链，特别是磷酸化丝氨酸和羟基化酪氨酸（多巴），具有高表面亲和力，形成配位表面复合物。在作为流体输送到表面后，永久性天然粘合剂固化以承受持续的负荷。贻贝斑块组装的方式表面上让人想起在体外逐层的策略，与顺序交付层通过Fe（多巴）3配位键。沙虫、石蛾幼虫和藤壶的粘合剂可以以有点类似于体外复合凝聚的形式递送。海洋粘合剂被分泌或排泄到海水中，海水的pH值和离子强度明显高于内部环境。经验证据表明，这些环境触发器可以提供最小化的、故障安全的定时机制，以防止分泌系统内的胶过早固化（不溶解），但允许在分泌后快速固化。水下生物粘合剂通过二次共价固化进一步增强。
The general topic of this review is protein-based underwater adhesives produced by aquatic organisms. The focus is on mechanisms of interfacial adhesion to native surfaces and controlled underwater solidification of natural water-borne adhesives. Four genera that exemplify the broad range of function, general mechanistic features, and unique adaptations are discussed in detail: blue mussels, acorn barnacles, sandcastle worms, and freshwater caddisfly larva. Aquatic surfaces in nature are charged and in equilibrium with their environment, populated by an electrical double layer of ions as well as adsorbed natural polyelectrolytes and microbial biofilms. Surface adsorption of underwater bioadhesives likely occurs by exchange of surface bound ligands by amino acid sidechains, driven primarily by relative affinities and effective concentrations of polymeric functional groups. Most aquatic organisms exploit modified amino acid sidechains, in particular phosphorylated serines and hydroxylated tyrosines (dopa), with high-surface affinity that form coordinative surface complexes. After delivery to the surfaces as a fluid, permanent natural adhesives solidify to bear sustained loads. Mussel plaques are assembled in a manner superficially reminiscent of in vitro layer-by-layer strategies, with sequentially delivered layers associated through Fe(dopa)3 coordination bonds. The adhesives of sandcastle worms, caddisfly larva, and barnacles may be delivered in a form somewhat similar to in vitro complex coacervation. Marine adhesives are secreted, or excreted, into seawater that has a significantly higher pH and ionic strength than the internal environment. Empirical evidence suggests these environment triggers could provide minimalistic, fail-safe timing mechanisms to prevent premature solidification (insolubilization) of the glue within the secretory system, yet allow rapid solidification after secretion. Underwater bioadhesives are further strengthened by secondary covalent curing.
登录
查看更多内容
影响因子：
14
作者：
Brubaker, Carrie E.;Kissler, Hermann;Wang, Ling-Jia;Kaufman, Dixon B.;Messersmith, Phillip B.
通讯作者：
Messersmith, Phillip B.
影响因子：
3.9
作者：
Connor, PA;McQuillan, AJ
通讯作者：
McQuillan, AJ
影响因子：
2.8
作者：
Dickinson, Gary H.;Vega, Irving E.;Rittschof, Daniel
通讯作者：
Rittschof, Daniel
影响因子：
3.9
作者：
Aldred, N;Ista, LK;Clare, AS
通讯作者：
Clare, AS
影响因子：
3.9
作者：
Callow, JA;Callow, ME;Chaudhury, MK
通讯作者：
Chaudhury, MK