Endothelium and responsiveness of vascular smooth muscle.
Endothelium and responsiveness of vascular smooth muscle.
复制标题
内皮和血管平滑肌的反应性。
DOI：
--
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
P. Vanhoutte
中科院分区：
文献类型：
--
作者：
P. Vanhoutte
多种动脉的内皮可以释放一种有效的血管舒张物质（内皮源性舒张因子）。内皮源性松弛因子引起平滑肌细胞的松弛与鸟苷酸环化酶的激活有关。在一定条件下，内皮细胞也能产生收缩因子。内皮功能障碍可导致下层平滑肌的异常行为，如血管痉挛。
The endothelium of a wide variety of arteries can release a potent vasodilator substance (endothelium-derived relaxing factor). The relaxation of smooth muscle cells evoked by endothelium-derived relaxing factor is associated with activation of guanylate cyclase. Under certain conditions the endothelium can produce contracting factors as well. Dysfunction of the endothelium may lead to abnormal behaviour of the underlying smooth muscle, e.g. vasospasm.