Origin of highly pathogenic H5N1 avian influenza virus in China and genetic characterization of donor and recipient viruses
Origin of highly pathogenic H5N1 avian influenza virus in China and genetic characterization of donor and recipient viruses
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DOI：
10.1099/vir.0.83129-0
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发表时间：
2007-11-01
影响因子：
3.8
通讯作者：
Wu, Jianguo
中科院分区：
文献类型：
--
作者：
Mukhtar, Muhammad Mahmood;Rasool, Sahibzada T.;Wu, Jianguo
1992年中国从江西省分离的两株南昌禽流感病毒A/Duck/南昌/1681/92(H3N8-1681)和A/Duck/南昌/1904/92(H7N1-1904)的全部8个基因的基因分析表明，H3N8-1681病毒的6个内部基因和H7N1-1904病毒的5个内部基因(NS基因除外)与亚洲第一株H5N1亚型高致病性禽流感病毒A/Goose/广东/1/96(H5N1)非常相似。Gs/Gd/1/96株神经氨酸酶(NA)基因与A/Duck/Hokkaido/55/96(H1N1-55)毒株的遗传相似性最高。Gs/Gd/1/96病毒的血凝素(HA)基因可能是A/Swan/Hokkaido/51/96(H5N3-51)样病毒H5 HA基因突变的结果。H5N3-51株PA基因与Gs/Gd/1/96株同源性最高。这项研究通过对南昌(靠近广东)和北海道(日本)(H1N1-55和H5N3-51)病毒的重新分类，解释了广东首例亚洲HPAI H5N1病毒的起源。对供体和受体病毒的基因特征也进行了研究。
Genetic analysis of all eight genes of two Nanchang avian influenza viruses, A/Duck/Nanchang/1681/92 (H3N8-1681) and A/Duck/Nanchang/1904/92 (H7N1-1904), isolated from Jiangxi province, China, in 1992, showed that six internal genes of H3N8-1681 virus and five internal (except NS gene) genes of H7N1-1904 virus were closely similar to A/Goose/Guangdong/1/96 (H5N1) virus, the first highly pathogenic avian influenza (HPAI) virus of subtype H5N1 isolated in Asia. The neuraminidase (NA) gene of Gs/Gd/1/96 had the highest genetic similarity with A/Duck/Hokkaido/55/96 (H1N1-55) virus. The haemagglutinin (HA) gene of Gs/Gd/1/96 virus might have originated as a result of mutation of H5 HA gene from A/Swan/Hokkaido/51/96 (H5N3-51)-like viruses. The PA gene of H5N3-51 virus had the highest similarity with Gs/Gd/1/96. This study explains the origin of first Asian HPAI H5N1 virus in Guangdong by the reassortment of Nanchang (close to Guangdong) and Hokkaido (Japan) (H1N1-55 and H5N3-51) viruses. Genetic characteristics of donor and recipient viruses were also studied.