THE SIGNIFICANCE OF SLEEP ONSET AND SLOW-WAVE SLEEP FOR NOCTURNAL RELEASE OF GROWTH-HORMONE (GH) AND CORTISOL
THE SIGNIFICANCE OF SLEEP ONSET AND SLOW-WAVE SLEEP FOR NOCTURNAL RELEASE OF GROWTH-HORMONE (GH) AND CORTISOL
复制标题
DOI：
10.1016/0306-4530(88)90021-2
复制
发表时间：
1988-01-01
影响因子：
3.7
通讯作者：
FEHM, HL
中科院分区：
文献类型：
--
作者：
BORN, J;MUTH, S;FEHM, HL
本实验旨在比较延迟睡眠和间歇性慢波睡眠(SWS)剥夺对人夜间GH和皮质醇释放的影响。多导睡眠图记录和血样来自10名男性受试者，每个受试者都参加了三个实验之夜。在所有的夜晚，受试者在2300h上床睡觉，在700h被叫醒。在基线之夜，灯在2300h被关闭，使受试者能够入睡。为了延缓入睡，在第二个晚上，受试者一直保持清醒到0200h。在第三个晚上，受试者在2300h到0200h之间被剥夺SWS。当受试者似乎进入第三阶段睡眠时，通过发出声音来完成SWS剥夺。实验条件的顺序是随机的。在基线夜间，SWS的发生与GH分泌爆发的发生密切相关，当时血浆皮质醇浓度较低。在0200h后延迟睡眠，大大延迟了GH分泌爆发，这再次与SWS的初始阶段相吻合。在2300h至0200h之间剥夺SWS并没有显著减少在SWS中花费的时间，因为停止剥夺后，SWS的时间就会恢复。在这些夜晚，生长激素分泌峰的幅度没有明显变化。然而，它们与SWS无关，因为它们大多发生在睡眠开始后，而不是在SWS发生的主要时期，发生在0200h之后。夜间皮质醇释放明显延迟，睡眠开始延迟，而暂时的SWS抑制没有明显的效果。因此，夜间生长激素和皮质醇分泌的时间似乎更多地取决于睡眠开始时间，而不是SWS。
The present experiments were designed to compare the influences of delayed sleep onset and temproary slow wave sleep (SWS) deprivation on nocuturnal GH and cortisol release in humans. Polysomnographic recordings and blood samples were obtained from 10 male subjects each participating on three experimental nights. On all nights the subjects went to bed at 2300 h and were wakened at 0700 h. On the baseline night, the lights were turned off at 2300 h, enabling the subject to fall asleep. To delay sleep onset, on the second night, the subjects were kept awake until 0200 h. On the third night, the subjects were deprived of SWS between 2300 h and 0200 h. SWS deprivation was accomplished by sounding a tone as soon as it appeared the subject was going into stage 3 sleep. The order of experimental conditions was randomized. On the baseline nights, the occurrence of SWS was closely associated with the occurrence of GH secretory bursts, and plasma cortisol concentrations were low at that time. Delaying sleep onset after 0200 h substantially delayed the GH secretory bursts, which again coincided with the initial periods of SWS. Deprivation of SWS between 2300 h and 0200 h did not significantly reduce the time spent in SWS, because it recovered after the deprivation was discontinued. On these nights, the GH secretory peaks were not significantly changed in amplitude. However, they were dissociated from SWS, because they occurred mostly subsequent to sleep onset rather than during the main epochs of SWS occuring after 0200 h. Nocturnal cortisol release was distinctly delayed with delayed sleep onset, whereas temporary SWS suppression had no significant effect. Thus, the timing of both nocturnal GH and cortisol secretion seems more dependent on sleep onset than on SWS.